Interleukin-17 and Its Implication in the Regulation of Differentiation and Function of Hematopoietic and Mesenchymal Stem Cells

被引：25

作者：

Mojsilovic, Slavko ^{[1
]}

Jaukovic, Aleksandra ^{[1
]}

Santibanez, Juan F. ^{[1
]}

Bugarski, Diana ^{[1
]}

机构：

[1] Univ Belgrade, Inst Med Res, Lab Expt Hematol & Stem Cells, Belgrade 11129, Serbia

来源：

MEDIATORS OF INFLAMMATION | 2015年 / 2015卷

关键词：

NECROSIS-FACTOR-ALPHA; STROMAL CELLS; BONE-MARROW; IL-17; RECEPTOR; RHEUMATOID-ARTHRITIS; CYTOKINE RELEASE; IN-VITRO; T-CELLS; OSTEOGENIC DIFFERENTIATION; SIGNAL-TRANSDUCTION;

D O I：

10.1155/2015/470458

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Adult stem cells have a great potential applicability in regenerative medicine and cell-based therapies. However, there are still many unresolved issues concerning their biology, and the influence of the local microenvironment on properties of stem cells has been increasingly recognized. Interleukin (IL-) 17, as a cytokine implicated in many physiological and pathological processes, should be taken into consideration as a part of a regulatory network governing tissue-associated stem cells' fate. This review is focusing on the published data on the effects of IL-17 on the properties and function of hematopoietic and mesenchymal stem cells and trying to discuss that IL-17 achieves many of its roles by acting on adult stem cells.

引用

页数：11

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