Signaling pathways modulated by miRNAs in breast cancer angiogenesis and new therapeutics

被引：26

作者：

Hussen, Bashdar Mahmud ^{[1
,3
]}

Salihi, Abbas ^{[2
,3
]}

Abdullah, Sara Tharwat ^{[4
]}

Rasul, Mohammed Fatih ^{[5
]}

Hidayat, Hazha Jamal ^{[6
]}

Hajiesmaeili, Mohammadreza ^{[7
]}

Ghafouri-Fard, Soudeh ^{[8
]}

机构：

[1] Hawler Med Univ, Coll Pharm, Dept Pharmacognosy, Erbil, Kurdistan Regio, Iraq

[2] Salahaddin Univ Erbil, Coll Sci, Dept Biol, Erbil, Kurdistan Regio, Iraq

[3] Lebanese French Univ, Ctr Res & Strateg Studies, Erbil, Kurdistan Regio, Iraq

[4] Hawler Med Univ, Coll Pharm, Dept Pharmacol & Toxicol, Erbil, Iraq

[5] Tishk Int Univ Erbil, Fac Sci, Dept Med Anal, Erbil, Iraq

[6] Salahaddin Univ Erbil, Coll Educ, Dept Biol, Erbil, Kurdistan Regio, Iraq

[7] Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Skull Base Res Ctr, Tehran, Iran

[8] Shahid Beheshti Univ Med Sci, Sch Med, Dept Med Genet, Tehran, Iran

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2022年 / 230卷

关键词：

Breast cancer; Tumor angiogenesis; MiRNA; VEGF; MiRNA delivery; Therapy; NF-KAPPA-B; ENDOTHELIAL GROWTH-FACTOR; INHIBITS TUMOR ANGIOGENESIS; DOWN-REGULATION; MESENCHYMAL TRANSITION; ANTI-ANGIOGENESIS; SMALL RNAS; CELLS; METASTASIS; DELIVERY;

D O I：

10.1016/j.prp.2022.153764

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

MicroRNAs (miRNAs) act as oncogenes or tumor suppressors by suppressing the expression of target genes, some of which are engaged in angiogenic signaling pathways directly or indirectly. Tumor development and metastasis are dependent on angiogenesis, and it is the main reason for the poor prognosis of cancer patients. New blood vessels are formed from pre-existing vessels when angiogenesis occurs. Thus, it is essential to develop primary tumors and the spread of cancer to surrounding tissues. MicroRNAs (miRNAs) are small noncoding RNAs involved in various biological processes. They can bind to the 3 '-UTR of their target genes and prevent them from expressing. MiRNAs control the activity of endothelial cells (ECs) through altering many biological pathways, which plays a key role in cancer progression and angiogenesis. Recent findings revealed that tumor-derived extracellular vesicles participated directly in the control of tumor angiogenesis by delivering miRNAs to ECs. miRNAs recently show great promise in cancer therapies to inhibit angiogenesis. In this study, we showed the miRNA-regulated signaling pathways in tumor angiogenesis with highlighting the anti-angiogenic therapy response and miRNA delivery methods that have been used to inhibit angiogenesis in both in vivo and in vitro studies.

引用

页数：14

共 162 条

[1] miR-200 Expression Regulates Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells and Reverses Resistance to Epidermal Growth Factor Receptor Therapy [J].