Synthesis, crystal structure, cytotoxic and apoptotic activity of 2,4-dichloro-6-methylquinoline on human oral carcinoma cell line

被引：7

作者：

Somvanshi, R. K. ^{[1
]}

Subashini, R. ^{[2
]}

Dhanasekaran, V. ^{[2
]}

Arulprakash, G. ^{[2
]}

Das, S. N. ^{[3
]}

Dey, S. ^{[1
]}

机构：

[1] All India Inst Med Sci, Dept Biophys, New Delhi 110029, India

[2] Vellore Inst Technol, Sch Sci & Humanities, Div Chem, Vellore 632014, Tamil Nadu, India

[3] All India Inst Med Sci, Dept Biotechnol, New Delhi 110029, India

来源：

JOURNAL OF CHEMICAL CRYSTALLOGRAPHY | 2008年 / 38卷 / 05期

关键词：

aryl amine; malonic acid; 2,4-dichloro-6-methylquinoline; crystal structure; flow cytometry; apoptosis;

D O I：

10.1007/s10870-007-9305-7

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

The present report describes the synthesis, IR spectra, 3-dimensional structure of the compound 2,4-dichloro-6-methylquinoline and evaluation of its anti-cancer activity using propidium iodide (PI) staining and annexin binding assay techniques. This derivative of quinoline was synthesized from the mixture of p-toluidine and malonic acid and synthesis has been achieved in a one-pot reaction from an aryl amine, malonic acid and phosphorous oxychloride. Crystallographic data reveals that the crystals belong to triclinic crystal system with space group P-1 with the unit cell dimensions of a = 7.14(1) angstrom, b = 11.53(1) angstrom, c = 11.97(1) angstrom and alpha = 90.18 degrees (10), beta = 106.31 degrees (10), gamma = 91.07 degrees (10). The in vitro anti-cancer assay indicated that compound has cytotoxic and apoptotic activity on human oral squamous carcinoma (KB) cell line, thus it could be developed as a potent anti-cancer agent.

引用

页码：381 / 386

页数：6

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