The role of TNF-α and anti-TNF-α agents in the immunopathogenesis and management of immune dysregulation in primary immunodeficiency diseases

被引：11

作者：

Abubakar, Sharafudeen Dahiru ^{[1
,2
]}

Ihim, Stella Amarachi ^{[3
,4
]}

Farshchi, Amir ^{[5
]}

Maleknia, Shayan ^{[5
]}

Abdullahi, Hamisu ^{[6
]}

Sasaki, Takanori ^{[7
,8
]}

Azizi, Gholamreza ^{[9
]}

机构：

[1] Tokyo Univ Sci, Res Inst Biomed Sci, Div Mol Pathol, Tokyo, Japan

[2] Ahmadu Bello Univ, Coll Med Sci, Dept Med Lab Sci, Zaria, Nigeria

[3] Univ Shizuoka, Dept Mol & Cellular Pharmacol, Shizuoka, Japan

[4] Univ Nigeria, Dept Pharmacol & Toxicol, Nsukka, Nigeria

[5] Alborz Univ Med Sci, Biopharmaceut Res Ctr, AryoGen Pharmed Inc, Karaj, Iran

[6] Usmanu Danfodiyo Univ Sokoto, Sch Med Lab Sci, Dept Immunol, Sokoto, Nigeria

[7] Brigham & Womens Hosp, Dept Med, Div Rheumatol Immunol & Allergy, Harvard Med Sch, 75 Francis St, Boston, MA 02115 USA

[8] Keio Univ, Dept Internal Med, Div Rheumatol, Sch Med, Tokyo, Japan

[9] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2022年 / 44卷 / 02期

关键词：

Primary immunodeficiency diseases; common variable immunodeficiency; autoimmune diseases; inflammatory diseases; tumor necrosis factor alpha; infliximab; etanercept; adalimumab; TUMOR-NECROSIS-FACTOR; COMMON VARIABLE IMMUNODEFICIENCY; LEUKOCYTE ADHESION DEFICIENCY; CROHNS-LIKE DISEASE; GRANULOMATOUS-DISEASE; T-CELLS; PYODERMA-GANGRENOSUM; CUTANEOUS GRANULOMAS; INFLIXIMAB; SUPERFAMILY;

D O I：

10.1080/08923973.2021.2023173

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Primary immunodeficiency diseases (PIDs) consist of a heterogeneous group of genetically disorders that affect distinct components of the immune system. They manifest as increased susceptibility to life-threatening infections, as well as autoimmunity and inflammatory disease. Among them, patients with diseases of immune dysregulation and autoinflammatory disorders are more complicated with autoimmunity. On the other hand, tumor necrosis factor alpha (TNF-alpha) is one of the major players in the pathogenesis of autoimmunity and inflammation in PID patients. Monoclonal antibodies (mAbs) targeting TNF-alpha would be a potential approach as a therapeutic tool for these diseases. In the current review, we aimed to highlight the characteristics of TNF-alpha and its important role in the pathogenesis of related complication in PID diseases. Critical evaluation of the mAbs targeting TNF-alpha (e.g. infliximab, etanercept, and adalimumab) in various immune-mediated complications in PID diseases will be provided, and finally, their clinical efficacy and safety will be reported.

引用

页码：147 / 156

页数：10

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