Enzyme-Responsive Delivery of Multiple Proteins with Spatiotemporal Control

被引：75
|
作者：
Zhu, Suwei [1 ]
Nih, Lina [1 ]
Carmichael, S. Thomas [2 ]
Lu, Yunfeng [1 ]
Segura, Tatiana [1 ]
机构：
[1] Univ Calif Los Angeles, Dept Chem & Biomol Engn, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA
来源：
ADVANCED MATERIALS | 2015年 / 27卷 / 24期
基金：
美国国家卫生研究院;
关键词：
ENDOTHELIAL GROWTH-FACTOR; ANGIOGENESIS; EXPRESSION; PDGF;
D O I：
10.1002/adma.201500417
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Orchestrated biological materials such as enzymes and growth factors regulate the growth of tissues and organs. A chirality-controlled, single-protein technology is devised to tailor the spatiotemporally defined delivery of therapeutic proteins in response to natural enzymes present at wound sites. Sustained delivery of one protein and sequential delivery of two proteins are demonstrated for stroke and skin wound healing.
引用
收藏
页码：3620 / 3625
页数：6
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