Antibodies in the Treatment of Aplastic Anemia

被引：15

作者：

Gomez-Almaguer, David ^{[1
]}

Carlos Jaime-Perez, Jose ^{[1
]}

Ruiz-Arguelles, Guillermo J. ^{[2
]}

机构：

[1] Univ Hosp, Hematol Serv, UANL, Monterrey 64610, NL, Mexico

[2] Ctr Hematol & Med Interna Puebla, Puebla, Mexico

来源：

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS | 2012年 / 60卷 / 02期

关键词：

Aplastic anemia; Antibodies; Alemtuzumab; Antithymocyte globulin; RABBIT ANTITHYMOCYTE GLOBULIN; ALEMTUZUMAB PLUS CYCLOSPORINE; COLONY-STIMULATING FACTOR; ANTI-THYMOCYTE GLOBULIN; IMMUNOSUPPRESSIVE THERAPY; ANTILYMPHOCYTE GLOBULIN; MARROW FAILURE; FOLLOW-UP; RITUXIMAB; CHILDREN;

D O I：

10.1007/s00005-012-0164-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antibodies have been the cornerstone of treatment of acquired aplastic anemia for more than 25 years. Treatment with antithymocyte globulin (ATG) is considered pivotal and the addition of cyclosporine improves the overall response rate. This antibody is heterogeneous and horse ATG is apparently more effective than rabbit ATG. Several issues remain unsolved in relation to the combination of ATG and cyclosporine: cost, toxicity and late clonal disorders. In recent years, alternative immunosuppressive therapy has been proposed and new antibodies have emerged: porcine ATG, alemtuzumab, daclizumab, and rituximab. Experience with these antibodies is limited to a few studies with alemtuzumab being the most promising, but the results are interesting and provocative. More studies are needed to find the perfect antibody.

引用

页码：99 / 106

页数：8

共 62 条

[1] Comparison between horse and rabbit antithymocyte globulin as first-line treatment for patients with severe aplastic anemia: a single-center retrospective study [J].

Atta, Elias Hallack ;

Saldanha, Danielle ;

Dias, Peixoto ;

Marra, Vera Lucia Neves ;

de Azevedo, Alexandre Mello .

ANNALS OF HEMATOLOGY, 2010, 89 (09) :851-859

[2] ANTILYMPHOCYTE GLOBULIN, CYCLOSPORINE, AND GRANULOCYTE-COLONY-STIMULATING FACTOR IN PATIENTS WITH ACQUIRED SEVERE APLASTIC-ANEMIA (SAA) - A PILOT-STUDY OF THE EBMT SAA WORKING PARTY [J].

BACIGALUPO, A ;

BROCCIA, G ;

CORDA, G ;

ARCESE, W ;

CAROTENUTO, M ;

GALLAMINI, A ;

LOCATELLI, F ;

MORI, PG ;

SARACCO, P ;

TODESCHINI, G ;

COSER, P ;

IACOPINO, P ;

VANLINT, MT ;

GLUCKMAN, E .

BLOOD, 1995, 85 (05) :1348-1353

[3] The Use of Anti-Human T Lymphocyte Porcine Immunogiobulin and Cyclosporine A to Treat Patients with Acquired Severe Aplastic Anemia [J].

Han Bing ;

Yan Siyi ;

Zhang Wei ;

Li Jian ;

Duan Minghui ;

Jiao Li ;

Wang Shujie ;

Zhou Daobin ;

Zou Nong ;

Zhu Tienan ;

Xu Ying ;

Zhao Yongqiang ;

Shen Ti .

ACTA HAEMATOLOGICA, 2010, 124 (04) :245-250

[4] Danazol as first-line therapy for aplastic anemia [J].

Carlos Jaime-Perez, Jose ;

Colunga-Pedraza, Perla R. ;

Gomez-Ramirez, Cynthia D. ;

Gutierrez-Aguirre, Cesar H. ;

Cantu-Rodriguez, Olga G. ;

Tarin-Arzaga, Luz C. ;

Gomez-Almaguer, David .

ANNALS OF HEMATOLOGY, 2011, 90 (05) :523-527

[5] Rituximab therapy of severe aplastic anemia induced by fludarabine and cyclophosphamide in a patient affected by B-cell chronic lymphocytic leukemia [J].

Castiglioni, M. G. ;

Scatena, P. ;

Pandolfo, C. ;

Mechelli, S. ;

Bianchi, M. .

LEUKEMIA & LYMPHOMA, 2006, 47 (09) :1985-1986

[6] ANTI-THYMOCYTE GLOBULIN TREATMENT IN PATIENTS WITH APLASTIC-ANEMIA - A PROSPECTIVE RANDOMIZED TRIAL [J].

CHAMPLIN, R ;

HO, W ;

GALE, RP .

NEW ENGLAND JOURNAL OF MEDICINE, 1983, 308 (03) :113-118

[7]

DELGADOLAMAS JL, 1989, ACTA HAEMATOL-BASEL, V81, P70

[8] Rabbit antithymocyte globulin (r-ATG) plus cyclosporine and granulocyte colony stimulating factor is an effective treatment for aplastic anaemia patients unresponsive to a first course of intensive immunosuppressive therapy [J].

Di Bona, E ;

Rodeghiero, E ;

Bruno, B ;

Gabbas, A ;

Foa, P ;

Locasciulli, A ;

Rosanelli, C ;

Camba, L ;

Saracco, P ;

Lippi, A ;

Iori, AP ;

Porta, F ;

De Rossi, V ;

Comotti, B ;

Iacopino, P ;

Dufour, C ;

Bacigalupo, A .

BRITISH JOURNAL OF HAEMATOLOGY, 1999, 107 (02) :330-334

[9] Changes in cytokine profile pre- and post-immunosuppression in acquired aplastic anemia [J].

Dufour, Carlo ;

Ferretti, Elisa ;

Bagnasco, Francesca ;

Burlando, Oriana ;

Lanciotti, Marina ;

Ramenghi, Ugo ;

Saracco, Paola ;

Van Lint, Maria Teresa ;

Longoni, Daniela ;

Torelli, Giovanni Fernando ;

Pillon, Marta ;

Locasciulli, Anna ;

Misuraca, Aldo ;

La Spina, Milena ;

Bacigalupo, Andrea ;

Pistoia, Vito ;

Corcione, Anna ;

Svahn, Johanna .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 (12) :1743-1747

[10] Antithymocyte globulin with or without cyclosporin A: 11-year follow-up of a randomized trial comparing treatments of aplastic anemia [J].

Frickhofen, N ;

Heimpel, H ;

Kaltwasser, JP ;

Schrezenmeier, H .

BLOOD, 2003, 101 (04) :1236-1242

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