A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects

被引：684

作者：

Tjalsma, Harold ^{[1
,2
]}

Boleij, Annemarie ^{[1
,2
]}

Marchesi, Julian R. ^{[3
]}

Dutilh, Bas E. ^{[4
,5
,6
]}

机构：

[1] N4i, Dept Lab Med, NL-6525 GA Nijmegen, Netherlands

[2] Radboud Univ Nijmegen Med Ctr, RUCO, NL-6525 GA Nijmegen, Netherlands

[3] Cardiff Univ, Sch Biosci, Cardiff CF10 3AT, S Glam, Wales

[4] Radboud Univ Nijmegen Med Ctr, Ctr Mol Biomol Informat, Nijmegen Ctr Mol Life Sci, NL-6525 GA Nijmegen, Netherlands

[5] San Diego State Univ, Dept Comp Sci, San Diego, CA 92182 USA

[6] San Diego State Univ, Dept Biol, San Diego, CA 92182 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2012年 / 10卷 / 08期

关键词：

ENTEROTOXIGENIC BACTEROIDES-FRAGILIS; COLON-CANCER; EXTRACELLULAR-SUPEROXIDE; INTESTINAL MICROBIOTA; STREPTOCOCCUS-BOVIS; INFECTIOUS CAUSES; GENOME SEQUENCE; STEM-CELLS; GALLOLYTICUS; ASSOCIATION;

D O I：

10.1038/nrmicro2819

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cancer has long been considered a genetic disease. However, accumulating evidence supports the involvement of infectious agents in the development of cancer, especially in those organs that are continuously exposed to microorganisms, such as the large intestine. Recent next-generation sequencing studies of the intestinal microbiota now offer an unprecedented view of the aetiology of sporadic colorectal cancer and have revealed that the microbiota associated with colorectal cancer contains bacterial species that differ in their temporal associations with developing tumours. Here, we propose a bacterial driver-passenger model for microbial involvement in the development of colorectal cancer and suggest that this model be incorporated into the genetic paradigm of cancer progression.

引用

页码：575 / 582

页数：8

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