Cellular Stress Associated with Aneuploidy

被引：151

作者：

Zhu, Jin ^{[1
]}

Tsai, Hung-Ji ^{[1
]}

Gordon, Molly R. ^{[1
]}

Li, Rong ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Dept Cell Biol, Ctr Cell Dynam, Sch Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Whiting Sch Engn, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA

来源：

DEVELOPMENTAL CELL | 2018年 / 44卷 / 04期

关键词：

PHA-STIMULATED LYMPHOCYTES; PLURIPOTENT STEM-CELLS; COPY-NUMBER VARIATION; DOWN-SYNDROME; CHROMOSOMAL INSTABILITY; SINGLE-CELL; GENOMIC INSTABILITY; PROTEOTOXIC STRESS; REPLICATION STRESS; DNA-REPLICATION;

D O I：

10.1016/j.devcel.2018.02.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aneuploidy, chromosome stoichiometry that deviates from exact multiples of the haploid compliment of an organism, exists in eukaryotic microbes, several normal human tissues, and the majority of solid tumors. Here, we review the current understanding about the cellular stress states that may result from aneuploidy. The topics of aneuploidy-induced proteotoxic, metabolic, replication, and mitotic stress are assessed in the context of the gene dosage imbalance observed in aneuploid cells. We also highlight emerging findings related to the downstream effects of aneuploidy-induced cellular stress on the immune surveillance against aneuploid cells.

引用

页码：420 / 431

页数：12

共 123 条

[21] Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy [J].

Chen, Guangbo ;

Bradford, William D. ;

Seidel, Chris W. ;

Li, Rong .

NATURE, 2012, 482 (7384) :246-250

[22] Gene Dosage Imbalance Contributes to Chromosomal Instability-Induced Tumorigenesis [J].

Clemente-Ruiz, Marta ;

Murillo-Maldonado, Juan M. ;

Benhra, Najate ;

Barrio, Lara ;

Perez, Lidia ;

Quiroga, Gonzalo ;

Nebreda, Angel R. ;

Milan, Marco .

DEVELOPMENTAL CELL, 2016, 36 (03) :290-302

[23] DNA breaks and chromosome pulverization from errors in mitosis [J].

Crasta, Karen ;

Ganem, Neil J. ;

Dagher, Regina ;

Lantermann, Alexandra B. ;

Ivanova, Elena V. ;

Pan, Yunfeng ;

Nezi, Luigi ;

Protopopov, Alexei ;

Chowdhury, Dipanjan ;

Pellman, David .

NATURE, 2012, 482 (7383) :53-U70

[24] Aicardi-Goutieres syndrome and the type I interferonopathies [J].

Crow, Yanick J. ;

Manel, Nicolas .

NATURE REVIEWS IMMUNOLOGY, 2015, 15 (07) :429-440

[25] HSF1 Guardian of Proteostasis in Cancer [J].

Dai, Chengkai ;

Sampson, Stephen Byers .

TRENDS IN CELL BIOLOGY, 2016, 26 (01) :17-28

[26] Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy [J].

Davoli, Teresa ;

Uno, Hajime ;

Wooten, Eric C. ;

Elledge, Stephen J. .

SCIENCE, 2017, 355 (6322)

[27] Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome [J].

Davoli, Teresa ;

Xu, Andrew Wei ;

Mengwasser, Kristen E. ;

Sack, Laura M. ;

Yoon, John C. ;

Park, Peter J. ;

Elledge, Stephen J. .

CELL, 2013, 155 (04) :948-962

[28] Estimates of the Live Births, Natural Losses, and Elective Terminations with Down Syndrome in the United States [J].

de Graaf, Gert ;

Buckley, Frank ;

Skotko, Brian G. .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2015, 167 (04) :756-767

[29] Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast [J].

Dephoure, Noah ;

Hwang, Sunyoung ;

O'Sullivan, Ciara ;

Dodgson, Stacie E. ;

Gygi, Steven P. ;

Amon, Angelika ;

Torres, Eduardo M. .

ELIFE, 2014, 3 :1-27

[30] Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy [J].

Deshaies, Raymond J. .

BMC BIOLOGY, 2014, 12

← 1 2 3 4 5 6 7 8 9 10 →