Cellular Stress Associated with Aneuploidy

被引：151

作者：

Zhu, Jin ^{[1
]}

Tsai, Hung-Ji ^{[1
]}

Gordon, Molly R. ^{[1
]}

Li, Rong ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Dept Cell Biol, Ctr Cell Dynam, Sch Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Whiting Sch Engn, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA

来源：

DEVELOPMENTAL CELL | 2018年 / 44卷 / 04期

关键词：

PHA-STIMULATED LYMPHOCYTES; PLURIPOTENT STEM-CELLS; COPY-NUMBER VARIATION; DOWN-SYNDROME; CHROMOSOMAL INSTABILITY; SINGLE-CELL; GENOMIC INSTABILITY; PROTEOTOXIC STRESS; REPLICATION STRESS; DNA-REPLICATION;

D O I：

10.1016/j.devcel.2018.02.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aneuploidy, chromosome stoichiometry that deviates from exact multiples of the haploid compliment of an organism, exists in eukaryotic microbes, several normal human tissues, and the majority of solid tumors. Here, we review the current understanding about the cellular stress states that may result from aneuploidy. The topics of aneuploidy-induced proteotoxic, metabolic, replication, and mitotic stress are assessed in the context of the gene dosage imbalance observed in aneuploid cells. We also highlight emerging findings related to the downstream effects of aneuploidy-induced cellular stress on the immune surveillance against aneuploid cells.

引用

页码：420 / 431

页数：12

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