Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors

被引：297

作者：

de Lima, Silmara ^{[1
,2
,3
,7
]}

Koriyama, Yoshiki ^{[1
,2
,3
]}

Kurimoto, Takuji ^{[1
,2
,3
]}

Oliveira, Julia Teixeira ^{[7
]}

Yin, Yuqin ^{[1
,2
,3
]}

Li, Yiqing ^{[1
,2
,3
]}

Gilbert, Hui-Ya ^{[1
,2
]}

Fagiolini, Michela ^{[1
,2
,4
,6
]}

Blanco Martinez, Ana Maria ^{[7
]}

Benowitz, Larry ^{[1
,2
,3
,5
,6
]}

机构：

[1] Childrens Hosp, Lab Neurosci Res Neurosurg, Boston, MA 02115 USA

[2] Childrens Hosp, FM Kirby Neurobiol Ctr, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Dept Ophthalmol, Boston, MA 02115 USA

[6] Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02115 USA

[7] Univ Fed Rio de Janeiro, Ctr Hlth Sci, Inst Biomed Sci, Program Basic & Clin Neurosci, BR-21941902 Rio De Janeiro, Brazil

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2012年 / 109卷 / 23期

基金：

日本学术振兴会;

关键词：

oncomodulin; retina; pathfinding; gene therapy; RETINAL GANGLION-CELLS; ADENOASSOCIATED VIRAL VECTORS; TRANSGENIC MICE; ONCOMODULIN; SYSTEM; PROJECTIONS; EXPRESSION; PATTERNS; DELETION; REVEALS;

D O I：

10.1073/pnas.1119449109

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mature optic nerve cannot regenerate when injured, leaving victims of traumatic nerve damage or diseases such as glaucoma with irreversible visual losses. Recent studies have identified ways to stimulate retinal ganglion cells to regenerate axons part-way through the optic nerve, but it remains unknown whether mature axons can reenter the brain, navigate to appropriate target areas, or restore vision. We show here that with adequate stimulation, retinal ganglion cells are able to regenerate axons the full length of the visual pathway and on into the lateral geniculate nucleus, superior colliculus, and other visual centers. Regeneration partially restores the optomotor response, depth perception, and circadian photoentrainment, demonstrating the feasibility of reconstructing central circuitry for vision after optic nerve damage in mature mammals.

引用

页码：9149 / 9154

页数：6

共 33 条

[1] Efferent retinal projections visualized by immunohistochemical detection of the estrogen-related receptor beta in the postnatal and adult mouse brain [J].