Updates in combined approaches of radiotherapy and immune checkpoint inhibitors for the treatment of breast cancer

被引：12

作者：

Jungles, Kassidy M. ^{[1
,2
,3
]}

Holcomb, Erin A. ^{[4
]}

Pearson, Ashley N. ^{[4
]}

Jungles, Kalli R. ^{[5
]}

Bishop, Caroline R. ^{[1
]}

Pierce, Lori J. ^{[1
,2
]}

Green, Michael D. ^{[1
,2
,6
,7
]}

Speers, Corey W. ^{[1
,2
,8
]}

机构：

[1] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Rogel Canc Ctr, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Pharmacol, Ann Arbor, MI USA

[4] Univ Michigan, Grad Program Immunol, Med Sch, Ann Arbor, MI USA

[5] St Marys Coll, Dept Biol, Notre Dame, IN USA

[6] Univ Michigan, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA

[7] Vet Affairs Ann Arbor Healthcare Syst, Dept Radiat Oncol, Ann Arbor, MI 48105 USA

[8] Case Western Reserve Univ, Univ Hosp Cleveland Med Ctr, Case Comprehens Canc Ctr, Dept Radiat Oncol, Cleveland, OH 44106 USA

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

关键词：

immune checkpoint inhibitors (ICI); radiotherapy; breast cancer; tumor immunology; radiation biology; immunotherapy; PEMBROLIZUMAB PLUS CHEMOTHERAPY; TUMOR-INFILTRATING LYMPHOCYTES; T-CELL THERAPY; RADIATION-THERAPY; ANTITUMOR IMMUNITY; NEOADJUVANT CHEMOTHERAPY; CONCURRENT PACLITAXEL; PD-L1; EXPRESSION; IMMUNOTHERAPY; BLOCKADE;

D O I：

10.3389/fonc.2022.1022542

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is the most prevalent non-skin cancer diagnosed in females and developing novel therapeutic strategies to improve patient outcomes is crucial. The immune system plays an integral role in the body's response to breast cancer and modulating this immune response through immunotherapy is a promising therapeutic option. Although immune checkpoint inhibitors were recently approved for the treatment of breast cancer patients, not all patients respond to immune checkpoint inhibitors as a monotherapy, highlighting the need to better understand the biology underlying patient response. Additionally, as radiotherapy is a critical component of breast cancer treatment, understanding the interplay of radiation and immune checkpoint inhibitors will be vital as recent studies suggest that combined therapies may induce synergistic effects in preclinical models of breast cancer. This review will discuss the mechanisms supporting combined approaches with radiotherapy and immune checkpoint inhibitors for the treatment of breast cancer. Moreover, this review will analyze the current clinical trials examining combined approaches of radiotherapy, immunotherapy, chemotherapy, and targeted therapy. Finally, this review will evaluate data regarding treatment tolerance and potential biomarkers for these emerging therapies aimed at improving breast cancer outcomes.

引用

页数：30

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