Highly practical "Ligand-Free-Like" copper-catalyzed N-arylation of azoles in lower nitrile solvents

被引：93

作者：

Zhu, Rui ^{[1
]}

Xing, Lixin ^{[1
]}

Wang, Xinyan ^{[1
]}

Cheng, Chuanjie ^{[1
]}

Su, Deyong ^{[1
]}

Hu, Yuefei ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Beijing 100084, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2008年 / 350卷 / 09期

关键词：

aryl halides; copper; heterocycles; ligand effects; nitriles; solvent effects;

D O I：

10.1002/adsc.200700535

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In lower nitrile solvents, the N-arylation of azoles with aryl halides was achieved efficiently in the presence of copper powder without any additional ligands. Thus, the first nitrile type of monodentate ligand-mediated, "ligand-free-like" coppercatalyzed N-arylation procedure was established.

引用

收藏

页码：1253 / 1257

页数：5

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