Spontaneous Contractility-Mediated Cortical Flow Generates Cell Migration in Three-Dimensional Environments

被引：110

作者：

Hawkins, Rhoda J. ^{[1
,2
,3
]}

Poincloux, Renaud ^{[2
]}

Benichou, Olivier ^{[1
]}

Piel, Matthieu ^{[2
]}

Chavrier, Philippe ^{[2
]}

Voituriez, Raphael ^{[1
]}

机构：

[1] Univ Paris 06, CNRS, UMR 7600, Paris, France

[2] Inst Curie, CNRS, UMR 144, F-75231 Paris, France

[3] Univ Bristol, Dept Math, Bristol BS8 1TW, Avon, England

来源：

BIOPHYSICAL JOURNAL | 2011年 / 101卷 / 05期

关键词：

ACTIN; DYNAMICS; MYOSIN; MICROTUBULES; REAR;

D O I：

10.1016/j.bpj.2011.07.038

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We present a model of cell motility generated by actomyosin contraction of the cell cortex. We identify, analytically, dynamical instabilities of the cortex and show that they yield steady-state cortical flows, which, in turn, can induce cell migration in three-dimensional environments. This mechanism relies on the regulation of contractility by myosin, whose transport is explicitly taken into account in the model. Theoretical predictions are compared to experimental data of tumor cells migrating in three-dimensional matrigel and suggest that this mechanism could be a general mode of cell migration in three-dimensional environments.

引用

页码：1041 / 1045

页数：5

共 29 条

[1]

Alberts B., 2002, The shape and structure of proteins, Vfourth, DOI 10.1093/aob/mcg023

[2] The dynamics of actin-based motility depend on surface parameters [J].