LINGO1 variants in essential tremor and Parkinson's disease

被引：24

作者：

Deng, H. ^{[1
,2
]}

Gu, S. ^{[1
,2
]}

Jankovic, J. ^{[3
]}

机构：

[1] Cent S Univ, Xiangya Hosp 3, Ctr Med Expt, Changsha 410013, HN, Peoples R China

[2] Cent S Univ, Xiangya Hosp 3, Dept Neurol, Changsha 410013, HN, Peoples R China

[3] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA

来源：

ACTA NEUROLOGICA SCANDINAVICA | 2012年 / 125卷 / 01期

基金：

中国国家自然科学基金;

关键词：

disease risk; essential tremor; genetics; LINGO1; Parkinson's disease; rs9652490; FUNCTIONAL RECOVERY; NOGO RECEPTOR; GENE; EXPRESSION; FAMILY; POPULATION; MUTATIONS; RS9652490; SYSTEM; GERMAN;

D O I：

10.1111/j.1600-0404.2011.01516.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The leucine-rich repeat and Ig domain containing 1 gene (LINGO1), recently considered to be conferred increased risk of essential tremor (ET), has been also implicated in Parkinson disease (PD). As the two common movement disorders have overlapping clinical and pathological features, it has been postulated that the LINGO1 gene may play a role in the pathogenesis of the two diseases. Here, we review published reports of the LINGO1 variants in ET and PD in an attempt to better understand the molecular and pathogenic relationship of LINGO1 to the two disorders.

引用

页码：1 / 7

页数：7

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