Left hemicranial hypoplasia in 2 patients with primary progressive aphasia

被引：13
作者：
Alberca, R
Montes, E
Russell, E
Gil-Néciga, E
Mesulam, M
机构：
[1] Northumbria Univ, Feinberg Sch Med, Cognit Neurol & Alzheimers Dis Ctr, Chicago, IL 60610 USA
[2] Virgen Rocio, Dept Neurol, Seville, Spain
[3] Northumbria Univ, Feinberg Sch Med, Dept Radiol, Chicago, IL 60610 USA
来源：
ARCHIVES OF NEUROLOGY | 2004年 / 61卷 / 02期
关键词：
D O I：
10.1001/archneur.61.2.265
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: Primary progressive aphasia (PPA) leads to a gradual and relatively isolated dissolution of language function. The factors that determine the selectivity of the disease process remain unknown. We had speculated that PPA may occasionally arise as a tardive manifestation of genetic or acquired vulnerabilities involving the language network of the brain. Objective: To explore predisposing factors for PPA. Results: In 2 patients, PPA developed with a background of mild left hemicranial hypoplasia. Conclusion: In keeping with other observations of PPA in patients with dyslexia and childhood injury to the left temporal lobe, these 2 patients support the contention that some cases of PPA may arise in settings where the language network has become a locus of least resistance.
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页码：265 / 268
页数：4
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