Anticancer effect of quinacrine on diffuse large B-cell lymphoma via inhibition of MSI2-NUMB signaling pathway

被引：10

作者：

Yang, Shujun ^{[1
]}

Sheng, Lixia ^{[1
]}

Xu, Kaihong ^{[1
]}

Wang, Yi ^{[1
]}

Zhu, Huiling ^{[1
]}

Zhang, Ping ^{[1
]}

Mu, Qitian ^{[1
]}

Ouyang, Guifang ^{[1
]}

机构：

[1] Ningbo First Hosp, Dept Hematol, 59 Liuting St, Ningbo 315010, Zhejiang, Peoples R China

来源：

MOLECULAR MEDICINE REPORTS | 2018年 / 17卷 / 01期

关键词：

diffuse large B-cell lymphoma; quinacrine; RNA-binding protein Musashi homolog 2-protein numb homolog signaling pathway; apoptosis; cell cycle; RNA-BINDING PROTEIN; NF-KAPPA-B; BREAST-CANCER CELLS; HEPATOCELLULAR-CARCINOMA; SMALL MOLECULES; DNA-BINDING; C-MYC; EXPRESSION; APOPTOSIS; NUMB;

D O I：

10.3892/mmr.2017.7892

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin's lymphoma. Despite improvements in the clinical outcomes of DLBCL, similar to 30% of patients will develop relapse/refractory disease. Therefore, novel therapeutic drugs have been investigated to improve disease outcomes. Previous studies have revealed the anticancer effects of quinacrine (QC) on tumor cells in vitro, although its role in human DLBCL is yet to be identified. The present study sought to examine the cytotoxic effect of QC on DLBCL cells. QC induced G0/G1 cell cycle arrest and apoptosis in the DLBCL cell lines SU-DHL-8 and OCI-LY01, in a dose-dependent manner, in addition to the downregulation of cyclin-dependent kinase 4/6 and the upregulation of cleaved poly-ADP ribose polymerase 1. Upon exposure to QC, RNA-binding protein Musashi homolog 2 inactivation and activation of protein numb homolog were observed. In addition, QC was able to inhibit the expression of Myc proto-oncogene protein. The results of the present study indicated that QC may be a potential anti-DLBCL drug.

引用

页码：522 / 530

页数：9

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