The role of Aβ peptides in Alzheimer's disease

被引：26
作者：
Tickler, AK
Wade, JD
Separovic, F [1 ]
机构：
[1] Univ Melbourne, Sch Chem, Melbourne, Vic 3010, Australia
[2] Univ Melbourne, Howard Florey Inst, Melbourne, Vic 3010, Australia
来源：
PROTEIN AND PEPTIDE LETTERS | 2005年 / 12卷 / 06期
关键词：
amyloid; A beta peptide; Alzheimer's disease; structure; therapeutic;
D O I：
10.2174/0929866054395905
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The A beta peptide has been identified as central to the onset and development of Alzheimer's disease (AD) and several hypotheses about toxicity involving A beta peptides have been proposed including mechanisms of oxidative stress and disruption of calcium homeostasis. The biology, structure and physical properties of A beta peptides are discussed, as well as existing therapeutics and future strategies for the treatment of AD.
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收藏
页码：513 / 519
页数：7
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