Advances and controversies in frontotemporal dementia: diagnosis, biomarkers, and therapeutic considerations

被引：120

作者：

Boeve, Bradley F. ^{[1
]}

Boxer, Adam L. ^{[2
]}

Kumfor, Fiona ^{[3
,4
]}

Pijnenburg, Yolande ^{[5
]}

Rohrer, Jonathan ^{[6
]}

机构：

[1] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA

[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

[3] Univ Sydney, Sch Psychol, Sydney, NSW, Australia

[4] Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia

[5] Vrije Univ Amsterdam, Amsterdam UMC, Alzheimer Ctr Amsterdam, Dept Neurol,Amsterdam Neurosci, Amsterdam, Netherlands

[6] Univ Coll London Queen Sq, Dementia Res Ctr, Inst Neurol, London, England

来源：

LANCET NEUROLOGY | 2022年 / 21卷 / 03期

基金：

英国医学研究理事会; 瑞典研究理事会;

关键词：

PRIMARY PROGRESSIVE APHASIA; NEUROFILAMENT LIGHT-CHAIN; BEHAVIORAL-VARIANT; LOBAR DEGENERATION; ALZHEIMERS-DISEASE; C9ORF72; TAU; MEMORY; NONFLUENT; COGNITION;

D O I：

10.1016/S1474-4422(21)00341-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Frontotemporal dementia comprises a group of clinical syndromes that are characterised by progressive changes in behaviour, executive function, or language. The term frontotemporal lobar degeneration encompasses the neurodegenerative diseases that give rise to these clinical syndromes and involve proteinopathies associated with frontotemporal network dysfunction. Improvements in clinical, genetic, and molecular characterisation have provided new insights into frontotemporal dementia and frontotemporal lobar degeneration, with a much broader range of signs and symptoms at presentation than has been previously considered. Accurate and early diagnosis of frontotemporal dementia is now a possibility due to development of neuropsychological measures with a special focus on social cognition. Advances in plasma and CSF biomarkers, and innovations in structural and functional imaging, will prove useful for future clinical trials in people with frontotemporal dementia.

引用

页码：258 / 272

页数：15

共 94 条

[1] The Overlapping Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia [J].

Abramzon, Yevgeniya A. ;

Fratta, Pietro ;

Traynor, Bryan J. ;

Chia, Ruth .

FRONTIERS IN NEUROSCIENCE, 2020, 14

[2] Frontotemporal dementia [J].

Bang, Jee ;

Spina, Salvatore ;

Miller, Bruce L. .

LANCET, 2015, 386 (10004) :1672-1682

[3] Longitudinal structural and metabolic changes in frontotemporal dementia [J].

Bejanin, Alexandre ;

Tammewar, Gautam ;

Marx, Gabe ;

Cobigo, Yann ;

Iaccarino, Leonardo ;

Kornak, John ;

Staffaroni, Adam M. ;

Dickerson, Bradford C. ;

Boeve, Bradley F. ;

Knopman, David S. ;

Gorno-Tempini, Marilu ;

Miller, Bruce L. ;

Jagust, William J. ;

Boxer, Adam L. ;

Rosen, Howard J. ;

Rabinovici, Gil D. .

NEUROLOGY, 2020, 95 (02) :E140-E154

[4] The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology [J].

Boeve, Bradley ;

Bove, Jessica ;

Brannelly, Patrick ;

Brushaber, Danielle ;

Coppola, Giovanni ;

Dever, Rielly ;

Dheel, Christina ;

Dickerson, Bradford ;

Dickinson, Susan ;

Faber, Kelley ;

Fields, Julie ;

Fong, Jamie ;

Foroud, Tatiana ;

Forsberg, Leah ;

Gavrilova, Ralitza ;

Gearhart, Debra ;

Ghoshal, Nupur ;

Goldman, Jennifer ;

Graff-Radford, Jonathan ;

Graff-Radford, Neill ;

Grossman, Murray ;

Haley, Dana ;

Heuer, Hilary ;

Hsiung, Ging-Yuek Robin ;

Huey, Edward ;

Irwin, David ;

Jones, David ;

Jones, Lynne ;

Kantarci, Kejal ;

Karydas, Anna ;

Knopman, David ;

Kornak, John ;

Kraft, Ruth ;

Kramer, Joel ;

Kremers, Walter ;

Kukull, Walter ;

Lapid, Maria ;

Lucente, Diane ;

Mackenzie, Ian ;

Manoochehri, Masood ;

McGinnis, Scott ;

Miller, Bruce ;

Pearlman, Rodney ;

Petrucelli, Len ;

Potter, Madeline ;

Rademakers, Rosa ;

Ramos, Eliana Marisa ;

Rankin, Kate ;

Rascovsky, Katya ;

Sengdy, Pheth .

ALZHEIMERS & DEMENTIA, 2020, 16 (01) :22-36

[5]

Botha Hugo, 2019, Continuum (Minneap Minn), V25, P101, DOI 10.1212/CON.0000000000000699

[6] New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures [J].

Boxer, Adam L. ;

Gold, Michael ;

Feldman, Howard ;

Boeve, Bradley F. ;

Dickinson, Susan L. -J. ;

Fillit, Howard ;

Ho, Carole ;

Paul, Robert ;

Pearlman, Rodney ;

Sutherland, Margaret ;

Verma, Ajay ;

Arneric, Stephen P. ;

Alexander, Brian M. ;

Dickerson, Bradford C. ;

Dorsey, Earl Ray ;

Grossman, Murray ;

Huey, Edward D. ;

Irizarry, Michael C. ;

Marks, William J. ;

Masellis, Mario ;

McFarland, Frances ;

Niehoff, Debra ;

Onyike, Chiadi U. ;

Paganoni, Sabrina ;

Panzara, Michael A. ;

Rockwood, Kenneth ;

Rohrer, Jonathan D. ;

Rosen, Howard ;

Schuck, Robert N. ;

Soares, Holly D. ;

Tatton, Nadine .

ALZHEIMERS & DEMENTIA, 2020, 16 (01) :131-143

[7] Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches [J].

Boxer, Adam L. ;

Yu, Jin-Tai ;

Golbe, Lawrence I. ;

Litvan, Irene ;

Lang, Anthony E. ;

Hoeglinger, Guenter U. .

LANCET NEUROLOGY, 2017, 16 (07) :552-563

[8] Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis [J].

Bridel, Claire ;

van Wieringen, Wessel N. ;

Zetterberg, Henrik ;

Tijms, Betty M. ;

Teunissen, Charlotte E. ;

Alvarez-Cermeno, Jose C. ;

Andreasson, Ulf ;

Axelsson, Markus ;

Backstrom, David C. ;

Bartos, Ales ;

Bjerke, Maria ;

Blennow, Kaj ;

Boxer, Adam ;

Brundin, Lou ;

Burman, Joachim ;

Christensen, Tove ;

Fialova, Lenka ;

Forsgren, Lars ;

Frederiksen, Jette L. ;

Gisslen, Magnus ;

Gray, Elizabeth ;

Gunnarsson, Martin ;

Hall, Sara ;

Hansson, Oskar ;

Herbert, Megan K. ;

Jakobsson, Joel ;

Jessen-Krut, Jan ;

Janelidze, Shorena ;

Johannsson, Gudmundur ;

Jonsson, Michael ;

Kappos, Ludwig ;

Khademi, Mohsen ;

Khalil, Michael ;

Kuhle, Jens ;

Landen, Mikael ;

Leinonen, Ville ;

Logroscino, Giancarlo ;

Lu, Ching-Hua ;

Lycke, Jan ;

Magdalinou, Nadia K. ;

Malaspina, Andrea ;

Mattsson, Niklas ;

Meeter, Lieke H. ;

Mehta, Sanjay R. ;

Modvig, Signe ;

Olsson, Tomas ;

Paterson, Ross W. ;

Perez-Santiago, Josue ;

Piehl, Fredrik ;

Pijnenburg, Yolande A. L. .

JAMA NEUROLOGY, 2019, 76 (09) :1035-1048

[9] Active lifestyles moderate clinical outcomes in autosomal dominant frontotemporal degeneration [J].

Casaletto, K. B. ;

Staffaroni, A. M. ;

Wolf, A. ;

Appleby, B. ;

Brushaber, D. ;

Coppola, G. ;

Dickerson, B. ;

Domoto-Reilly, K. ;

Elahi, F. M. ;

Fields, J. ;

Fong, J. C. ;

Forsberg, L. ;

Ghoshal, N. ;

Graff-Radford, N. ;

Grossman, M. ;

Heuer, H. W. ;

Hsiung, G. -Y. ;

Huey, E. D. ;

Irwin, D. ;

Kantarci, K. ;

Kaufer, D. ;

Kerwin, D. ;

Knopman, D. ;

Kornak, J. ;

Kramer, J. H. ;

Litvan, I. ;

Mackenzie, I. R. ;

Mendez, M. ;

Miller, B. ;

Rademakers, R. ;

Ramos, E. M. ;

Rascovsky, K. ;

Roberson, E. D. ;

Syrjanen, J. A. ;

Tartaglia, M. C. ;

Weintraub, S. ;

Boeve, B. ;

Boxer, A. L. ;

Rosen, H. ;

Yaffe, K. .

ALZHEIMERS & DEMENTIA, 2020, 16 (01) :91-105

[10] Rates of lobar atrophy in asymptomatic MAPT mutation carriers [J].

Chen, Qin ;

Boeve, Bradley F. ;

Senjem, Matthew ;

Tosakulwong, Nirubol ;

Lesnick, Timothy G. ;

Brushaber, Danielle ;

Dheel, Christina ;

Fields, Julie ;

Forsberg, Leah ;

Gavrilova, Ralitza ;

Gearhart, Debra ;

Graff-Radford, Jonathan ;

Graff-Radford, Neill R. ;

Jack, Clifford R., Jr. ;

Jones, David T. ;

Knopman, David S. ;

Kremers, Walter K. ;

Lapid, Maria ;

Rademakers, Rosa ;

Syrjanen, Jeremy ;

Boxer, Adam L. ;

Rosen, Howie ;

Wszolek, Zbigniew K. ;

Kantarci, Kejal .

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS, 2019, 5 (01) :338-346

← 1 2 3 4 5 6 7 8 9 10 →