Decoding the Role of Familial Parkinson's Disease-Related Genes in DNA Damage and Repair

被引：12

作者：

Li, Yao-Lin ^{[1
]}

Wang, Zhong-Xuan ^{[1
]}

Ying, Chang-Zhou ^{[1
]}

Zhang, Bao-Rong ^{[1
]}

Pu, Jia-Li ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Neurol, Hangzhou 310009, Zhejiang, Peoples R China

来源：

AGING AND DISEASE | 2022年 / 13卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Parkinson's disease; pathogenesis; Nuclear; DNA damage; DNA repair; DOUBLE-STRAND BREAKS; ATM PROTEIN-KINASE; ALPHA-SYNUCLEIN; NUCLEAR TRANSLOCATION; MUTATIONS; DJ-1; INCREASE; PATHWAY; BRAIN; EPIDEMIOLOGY;

D O I：

10.14336/AD.2022.0216

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Parkinson's disease (PD) is a neurodegenerative disease characterized by the degeneration of midbrain substantia nigra pars compacta dopaminergic neurons and the formation of Lewy bodies. Over the years, researchers have gained extensive knowledge about dopaminergic neuron degeneration from the perspective of the environmental and disease-causing genetic factors; however, there is still no disease-modifying therapy. Aging has long been recognized as a major risk factor for PD; however, little is known about how aging contributes to the disease development. Genome instability is the main driving force behind aging, and has been poorly studied in patients with PD. Here, we summarize the evidence for nuclear DNA damage in PD. We also discuss the molecular mechanisms of nuclear DNA damage and repair in PD, especially from the perspective of familial PD-related mutant genes. Understanding the significance of DNA damage and repair may provide new potential intervention targets for treating PD.

引用

页码：1405 / 1412

页数：8

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