Antimicrobial activity of tea catechin against canine oral bacteria and the functional mechanisms

被引：46

作者：

Bai, Lanlan ^{[1
]}

Takagi, Shiaki ^{[1
]}

Ando, Tasuke ^{[1
]}

Yoneyama, Hiroshi ^{[1
]}

Ito, Kumiko ^{[2
]}

Mizugai, Hiroyuki ^{[3
]}

Isogai, Emiko ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Agr Sci, Dept Microbial Biotechnol, Lab Anim Microbiol,Aoba Ku, 1-1 Tsutsumidori,Amamiya Machi, Sendai, Miyagi 9818555, Japan

[2] Tohoku Univ, Grad Sch Agr Sci, Aoba Ku, Electron Microscope Room,1-1 Tsutsumidori, Sendai, Miyagi 9818555, Japan

[3] Hlth Sci Univ Hokkaido, Dept Prevent Dent, Sch Dent, 1757 Kanazawa, Tobetsu, Hokkaido 0610293, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2016年 / 78卷 / 09期

关键词：

biofilm; EGCG; polyphenolic compounds; streptococcal lipoteichoic acid; STREPTOCOCCUS-MUTANS; PERIODONTAL-DISEASE; GREEN TEA; CAMELLIA-SINENSIS; TEICHOIC-ACIDS; BLACK TEA; DOGS; INFECTIONS; BIOFILMS; CARIES;

D O I：

10.1292/jvms.16-0198

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Epigallocatechin gallate (EGCG) is the major polyphenolic compound of green tea. Polyphenolic compounds were extracted from the leaf of Camellia sinensis (Japanese green tea), and the minimum inhibitory concentration against canine oral bacteria was measured. Subsequently, we investigated the inhibitory effects of polyphenolic compounds and EGCG on the growth of canine oral bacteria. EGCG showed antimicrobial activity against a model bacterium, Streptococcus mutans. Our results indicate that EGCG can inhibit the growth and biofilm formation of S. mutans and that EGCG does not interact with streptococcal lipoteichoic acid (LTA). Furthermore, our findings suggest that EGCG interacts with other component(s) of the bacterial membrane aside from streptococcal LTA to inhibit biofilm formation and damage biofilms.

引用

页码：1439 / 1445

页数：7

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