Structure-based design of inhibitors of human brain memapsin 2 (β-secretase).

被引：0
|
作者：
Ghosh, AK
Bilcer, G
Devasamudram, T
Hong, L
Koelsch, G
Tang, J
机构：
[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA
[2] Oklahoma Med Res Fdn, Prot Studies Program, Oklahoma City, OK USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 226卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
48-MEDI
引用
收藏
页码：U8 / U9
页数：2
相关论文
共 50 条
  • [1] Structure-based design:: Potent inhibitors of human brain memapsin 2 (β-secretase)
    Ghosh, AK
    Bilcer, G
    Harwood, C
    Kawahama, R
    Shin, D
    Hussain, KA
    Hong, L
    Loy, JA
    Nguyen, C
    Koelsch, G
    Ermolieff, J
    Tang, J
    JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (18) : 2865 - 2868
  • [2] Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (β-secretase)
    Ghosh, AK
    Devasamudram, T
    Hong, L
    DeZutter, C
    Xu, XM
    Weerasena, V
    Koelsch, G
    Bilcer, G
    Tang, J
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (01) : 15 - 20
  • [3] Design of potent inhibitors for human brain memapsin 2 (β-secretase)
    Ghosh, AK
    Shin, DW
    Downs, D
    Koelsch, G
    Lin, XL
    Ermolieff, J
    Tang, J
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (14) : 3522 - 3523
  • [4] Design of novel peptidic β-secretase (Memapsin 2) inhibitors
    Gonzalez, L
    Sussman, FS
    Villaverde, MC
    Estevez, RJ
    Estevez, JC
    BIOPHYSICAL JOURNAL, 2003, 84 (02) : 282A - 282A
  • [5] Structure-based design of a series of potent inhibitors of human f "-secretase
    Vacca, Joseph P.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
  • [6] In vivo inhibition of brain Aβ level by memapsin 2 (β-secretase) inhibitors
    Chang, WP
    Koelsch, G
    Wong, S
    Downs, D
    Da, HN
    Weerasena, V
    Gordon, B
    Devasamudram, T
    Bilcer, G
    Ghosh, AK
    Tang, J
    NEUROBIOLOGY OF AGING, 2004, 25 : S581 - S581
  • [7] In vivo inhibition of Aβ production by memapsin 2 (β-secretase) inhibitors
    Chang, WP
    Koelsch, G
    Wong, S
    Downs, D
    Da, HN
    Weerasena, V
    Gordon, B
    Devasamudram, T
    Bilcer, G
    Ghosh, AK
    Tang, J
    JOURNAL OF NEUROCHEMISTRY, 2004, 89 (06) : 1409 - 1416
  • [8] Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes
    Ghosh, Arun K.
    Reddy, Bhavanam Sekhara
    Yen, Yu-Chen
    Cardenas, Emilio L.
    Rao, Kalapala Venkateswara
    Downs, Deborah
    Huang, Xiangping
    Tang, Jordan
    Mesecarabc, Andrew D.
    CHEMICAL SCIENCE, 2016, 7 (05) : 3117 - 3122
  • [9] In vivo inhibition of Aβ production by memapsin 2(β-secretase) inhibitors
    Chang, WP
    Downs, D
    Tang, J
    Koelsch, G
    Ghosh, AR
    NEUROBIOLOGY OF AGING, 2002, 23 (01) : S134 - S134
  • [10] Structure-based design of a novel class of beta-secretase (BACE) inhibitors
    Reynolds, Charles H.
    Tounge, Brett A.
    Reitz, Allen B.
    Baxter, Ellen W.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 234
12345