EGFR tyrosine kinase inhibitors as first-line therapy in advanced EGFR mutation-positive non-small cell lung cancer: strategies to improve clinical outcome

被引:11
作者
Tiefenbacher, Andreas [1 ]
Pirker, Robert [1 ]
机构
[1] Med Univ Vienna, Dept Med 1, Wahringer Gurtel 18-20, A-1090 Vienna, Austria
关键词
CHEMOTHERAPY PLUS CETUXIMAB; PHASE-III TRIAL; OPEN-LABEL; BEVACIZUMAB; GROWTH; OSIMERTINIB; MULTICENTER; GEMCITABINE; CISPLATIN; ERLOTINIB;
D O I
10.21037/jtd.2017.10.02
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
引用
收藏
页码:4208 / 4211
页数:4
相关论文
共 19 条
[11]   Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial [J].
Pirker, Robert ;
Pereira, Jose R. ;
Szczesna, Aleksandra ;
von Pawel, Joachim ;
Krzakowski, Maciej ;
Ramlau, Rodryg ;
Vynnychenko, Ihor ;
Park, Keunchil ;
Yu, Chih-Teng ;
Ganul, Valentyn ;
Roh, Jae-Kyung ;
Bajetta, Emilio ;
O'Byrne, Kenneth ;
de Marinis, Filippo ;
Eberhardt, Wilfried ;
Goddemeier, Thomas ;
Emig, Michael ;
Gatzemeier, Ulrich ;
Pirker, R. ;
Thatcher, N. ;
Armand, J. P. ;
Camus, P. ;
Victor, N. ;
Emig, M. ;
Mueser, M. ;
Pilz, K. ;
Goddemeier, T. ;
Montaner, I. ;
Lachs, Martin ;
Hoang-Sayag, Loan ;
Alvarez, A. ;
Coppola, F. ;
Recondo, G. ;
Richardet, E. ;
Kirsten, F. ;
Karapetis, C. ;
Parente, P. ;
Michael, M. ;
White, S. ;
Boyce, A. ;
Lewis, C. ;
Slancar, M. ;
Pavlakis, N. ;
Abdi, E. ;
Underhill, C. ;
Pittman, K. ;
Burghuber, O. ;
Pirker, R. ;
Ruckser, R. ;
Ulsperger, E. .
LANCET, 2009, 373 (9674) :1525-1531
[12]   Meta-analysis of individual patient data from randomized trials of chemotherapy plus cetuximab as first-line treatment for advanced non-small cell lung cancer [J].
Pujol, Jean-Louis ;
Pirker, Robert ;
Lynch, Thomas J. ;
Butts, Charles A. ;
Rosell, Rafael ;
Shepherd, Frances A. ;
Vansteenkiste, Johan ;
O'Byrne, Kenneth J. ;
de Blas, Barbara ;
Heighway, Jim ;
von Heydebreck, Anja ;
Thatcher, Nick .
LUNG CANCER, 2014, 83 (02) :211-218
[13]  
Ramalingam S, 2017, ANN ONCOL, V28
[14]   Phase III Trial of Cisplatin Plus Gemcitabine With Either Placebo or Bevacizumab As First-Line Therapy for Nonsquamous Non-Small-Cell Lung Cancer: AVAiL [J].
Reck, Martin ;
von Pawel, Joachim ;
Zatloukal, Petr ;
Ramlau, Rodryg ;
Gorbounova, Vera ;
Hirsh, Vera ;
Leighl, Natasha ;
Mezger, Joerg ;
Archer, Venice ;
Moore, Nicola ;
Manegold, Christian .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (08) :1227-1234
[15]   Erlotinib and bevacizumab in patients with advanced non-small-cell lung cancer and activating EGFR mutations (BELIEF): an international, multicentre, single-arm, phase 2 trial [J].
Rosell, Rafael ;
Dafni, Urania ;
Felip, Enriqueta ;
Curioni-Fontecedro, Alessandra ;
Gautschi, Oliver ;
Peters, Solange ;
Massuti, Bartomeu ;
Palmero, Ramon ;
Ponce Aix, Santiago ;
Carcereny, Enric ;
Frueh, Martin ;
Pless, Miklos ;
Popat, Sanjay ;
Kotsakis, Athanasios ;
Cuffe, Sinead ;
Bidoli, Paolo ;
Favaretto, Adolfo ;
Froesch, Patrizia ;
Reguart, Noemi ;
Puente, Javier ;
Coate, Linda ;
Barlesi, Fabrice ;
Rauch, Daniel ;
Thomas, Michael ;
Camps, Carlos ;
Gomez-Codina, Jose ;
Majem, Margarita ;
Porta, Rut ;
Shah, Riyaz ;
Hanrahan, Emer ;
Kammler, Roswitha ;
Ruepp, Barbara ;
Rabaglio, Manuela ;
Kassapian, Marie ;
Karachaliou, Niki ;
Tam, Rachel ;
Shames, David S. ;
Molina-Vila, Miguel A. ;
Stahel, Rolf A. .
LANCET RESPIRATORY MEDICINE, 2017, 5 (05) :435-444
[16]   Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer [J].
Sandler, Alan ;
Gray, Robert ;
Perry, Michael C. ;
Brahmer, Julie ;
Schiller, Joan H. ;
Dowlati, Afshin ;
Lilenbaum, Rogerio ;
Johnson, David H. .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (24) :2542-2550
[17]   Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an open-label, randomised, multicentre, phase 2 study [J].
Seto, Takashi ;
Kato, Terufumi ;
Nishio, Makoto ;
Goto, Koichi ;
Atagi, Shinji ;
Hosomi, Yukio ;
Yamamoto, Noboru ;
Hida, Toyoaki ;
Maemondo, Makoto ;
Nakagawa, Kazuhiko ;
Nagase, Seisuke ;
Okamoto, Isamu ;
Yamanaka, Takeharu ;
Tajima, Kosei ;
Harada, Ryosuke ;
Fukuoka, Masahiro ;
Yamamoto, Nobuyuki .
LANCET ONCOLOGY, 2014, 15 (11) :1236-1244
[18]   Necitumumab plus gemcitabine and cisplatin versus gemcitabine and cisplatin alone as first-line therapy in patients with stage IV squamous non-small-cell lung cancer (SQUIRE): an open-label, randomised, controlled phase 3 trial [J].
Thatcher, Nick ;
Hirsch, Fred R. ;
Luft, Alexander V. ;
Szczesna, Aleksandro ;
Ciuleanu, Tudor E. ;
Dediu, Mircea ;
Ramlau, Rodryg ;
Galiulin, Rinat K. ;
Balint, Beatrix ;
Losonczy, Gyoergy ;
Kazarnowicz, Andrzej ;
Park, Keunchil ;
Schumann, Christian ;
Reck, Martin ;
Depenbrock, Henrik ;
Nanda, Shivani ;
Letunic, Anamarija Kruljac ;
Kurek, Raffacl ;
Paz-Ares, Luis ;
Socinskf, Mark A. .
LANCET ONCOLOGY, 2015, 16 (07) :763-774
[19]   Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway [J].
Wei, LH ;
Kuo, ML ;
Chen, CA ;
Chou, CH ;
Lai, KB ;
Lee, CN ;
Hsieh, CY .
ONCOGENE, 2003, 22 (10) :1517-1527