IN SILICO AND EXPERIMENTAL STUDIES FOR THE DEVELOPMENT OF NOVEL OXAZOL-5(4H)-ONES WITH PHARMACOLOGICAL POTENTIAL

被引：6

作者：

Rosca, Elena Valentina ^{[1
]}

Apostol, Theodora Venera ^{[1
]}

Chifiriuc, Mariana Carmen ^{[2
,3
]}

Pircalabioru, Gratiela Gradisteanu ^{[2
,3
]}

Draghici, Constantin ^{[4
]}

Socea, Laura Ileana ^{[1
]}

Olaru, Octavian Tudorel ^{[5
]}

Nitulescu, George Mihai ^{[6
]}

Pahontu, Elena Mihaela ^{[7
]}

Hrubaru, Madalina ^{[4
]}

Barbuceanu, Stefania Felicia ^{[1
]}

机构：

[1] Carol Davila Univ Med & Pharm, Fac Pharm, Organ Chem Dept, 6 Traian Vuia St, Bucharest 020956, Romania

[2] Univ Bucharest, Res Inst, ICUB, 1-3 Portocalelor Alley, Bucharest 060101, Romania

[3] Univ Bucharest, Fac Biol, Microbiol Dept, 1-3 Portocalelor Alley, Bucharest 060101, Romania

[4] Romanian Acad, Costin D Nenitescu Organ Chem Ctr, 202B Splaiul Independentei St, Bucharest 060023, Romania

[5] Carol Davila Univ Med & Pharm, Pharmaceut Bot & Cell Biol Dept, Fac Pharm, 6 Traian Vuia St, Bucharest 020956, Romania

[6] Carol Davila Univ Med & Pharm, Pharmaceut Chem Dept, Fac Pharm, 6 Traian Vuia St, Bucharest 020956, Romania

[7] Carol Davila Univ Med & Pharm, Gen & Inorgan Chem Dept, Fac Pharm, 6 Traian Vuia St, Bucharest 020956, Romania

来源：

FARMACIA | 2020年 / 68卷 / 03期

关键词：

oxazol-5(4H)-one; spectral characterization; cytotoxicity; antimicrobial activity; CYTOTOXICITY EVALUATION; ANTIBACTERIAL ACTIVITY; HETEROCYCLIC-COMPOUNDS; BIOLOGICAL EVALUATION; THIAZOLE SYNTHESIS; DERIVATIVES; OXAZOLE; DESIGN; 1,3,4-THIADIAZOLE; 1,2,4-TRIAZOLE;

D O I：

10.31925/farmacia.2020.3.10

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

New 2-(4-(4-X-phenylsulfonyl)phenyl)-4-(3-bromo/3-bromo-4-methoxy-benzylidene)oxazol-5(4H)-ones have been synthesized by reaction of some 2-(4-(4-X-phenylsulfonyl)benzamido)acetic acids derivatives with 3-bromobenzaldehyde or 3-bromo-4-methoxybenzaldehyde. The structures of the newly obtained heterocycles were elucidated by IR, H-1-NMR, C-13-NMR, mass spectra and elemental analysis. The cytotoxicity of the new oxazolones was evaluated using Artemia salina and Daphnia magna organisms and the in vitro antimicrobial activity was assessed on Gram-positive and Gram-negative bacterial and fungal strains.

引用

页码：453 / 462

页数：10

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