Genetic abberations in gallbladder cancer

被引：31
作者：
Maurya, Sanjeev K. [1 ]
Tewari, Mallika [1 ]
Mishra, Raghvendra R. [1 ]
Shukla, Hari S. [1 ]
机构：
[1] Banaras Hindu Univ, Inst Med Sci, Dept Surg Oncol, Varanasi 221005, UP, India
来源：
SURGICAL ONCOLOGY-OXFORD | 2012年 / 21卷 / 01期
关键词：
Genetic abnormality; Oncogenes; Tumor suppressor genes; Gallbladder carcinoma; GROWTH-FACTOR-RECEPTOR; BILIARY-TRACT CANCER; CYCLIN D1 OVEREXPRESSION; K-RAS; MICROSATELLITE INSTABILITY; ADENOCARCINOMA CELLS; TUMOR PROGRESSION; PROGNOSTIC-FACTOR; INDIAN PATIENTS; CRITICAL EVENT;
D O I：
10.1016/j.suronc.2010.09.003
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gallbladder carcinoma (GBC) is the most common type of biliary tract carcinoma and the third commonest digestive tract malignancy in our region. Studies available in literature do not clearly define the molecular genetic mechanisms involved in the pathogenesis of GBC. Most of these studies are limited to protein expression analysis by immunohistochemistry and western blotting, and only a few have been done on mRNA (messenger RNA) and mutation analysis. This review aims to critically analyze all the available evidence on genetic aberrations in gallbladder carcinoma. (C) 2010 Elsevier Ltd. All rights reserved.
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页码：37 / 43
页数：7
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