IGF-I and Visfatin Levels in Retinopathy of Prematurity

被引：10

作者：

Cekmez, Ferhat ^{[1
]}

Canpolat, Fuat Emre ^{[1
]}

Cetinkaya, Merih ^{[1
]}

Pirgon, Ozgur ^{[2
]}

Aydinoz, Secil ^{[2
]}

Ceylan, O. Melih ^{[3
]}

Ipcioglu, O. Metin ^{[4
]}

Sarici, Serdar Umit ^{[1
]}

机构：

[1] Gulhane Mil Med Acad, Dept Pediat, Div Neonatol, Ankara, Turkey

[2] Gulhane Mil Med Acad, Haydarpasa Mil Hosp, Dept Pediat, Istanbul, Turkey

[3] Gulhane Mil Med Acad, Haydarpasa Mil Hosp, Dept Ophthalmol, Istanbul, Turkey

[4] Gulhane Mil Med Acad, Haydarpasa Mil Hosp, Dept Biochem, Istanbul, Turkey

来源：

JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS | 2012年 / 49卷 / 02期

关键词：

BINDING-PROTEINS; INFANTS; WEIGHT; OXYGEN; BIRTH;

D O I：

10.3928/01913913-20110531-01

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: The authors hypothesized that circulating visfatin concentrations in preterm infants might be linked with retinopathy of prematurity (ROP)-like insulin-like growth factor I (IGF-I) levels. Methods: The study group comprised 88 children born with a gestational age younger than 32 weeks between 2007 and 2009 who were screened and/or treated for ROP. The authors collected fetal cord blood (sample 1) and a blood sample at 4 to 6 weeks postnatal age (sample 2) for laboratory investigations. Results: The non-ROP group had higher visfatin-1, visfatin-2, insulin-1, insulin-2, (IGF-I)-1, and (IGF-I)-2 levels than the ROP group (P < .001 for all levels). Change in visfatin was positively correlated with change in IGF-I and change in insulin (P < .001 and P < .001, respectively). Change in IGF-I was positively correlated with change in insulin (P < .001). Conclusion: Similar to IGF-I levels, determination of visfatin levels can be a predictive marker of ROP, but more studies are needed.

引用

页码：120 / 124

页数：5

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