Caveolin and proteasome in tocotrienol mediated myocardial protection

被引：31
作者：
Das, Manika
Das, Samarjit
Wang, Ping [2 ,3 ]
Powell, Saul R. [2 ,3 ]
Das, Dipak K. [1 ]
机构：
[1] Univ Connecticut, Cardiovasc Res Ctr, FAHA, Sch Med, Farmington, CT 06030 USA
[2] Feinstein Inst Med Res, Dept Med, New Hyde Pk, NY USA
[3] Albert Einstein Coll Med, New Hyde Pk, NY USA
来源：
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2008年 / 22卷 / 1-4期
关键词：
caveolin; proteasome; tocotrienol; heart; ischemia/reperfusion;
D O I：
10.1159/000149807
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The effect of different isomers of tocotrienol was tested on myocardial ischemia reperfusion injury. Although all of the tocotrienol isomers offered some degree of cardioprotection, gamma-tocotrienol was the most protective as evident from the result of myocardial apoptosis. To study the mechanism of tocotrienol mediated cardioprotection, we examined the interaction and/or translocation of different signaling components to caveolins and activity of proteasome. The results suggest that differential interaction of MAP kinases with caveolin 1/3 in conjuncture with proteasome stabilization play a unique role in tocotrienol mediated cardioprotection possibly by altering the availability of pro-survival and anti-survival proteins. Copyright (C) 2008 S. Karger AG, Basel.
引用
收藏
页码：287 / 294
页数：8
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