Tetrac-decorated chitosan-coated PLGA nanoparticles as a new platform for targeted delivery of SN38

被引：33
作者：
Alibolandi, Mona [1 ]
Farzad, Sara Amel [1 ]
Mohammadi, Marzieh [2 ,3 ]
Abnous, Khalil [1 ]
Taghdisi, Seyed Mohammad [4 ]
Kalalinia, Fatemeh [5 ]
Ramezani, Mohammad [1 ,2 ]
机构：
[1] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran
[2] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmaceut Nanotechnol, Mashhad, Iran
[3] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Nanotechnol Res Ctr, Mashhad, Iran
[4] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Targeted Drug Delivery Res Ctr, Mashhad, Iran
[5] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2018年 / 46卷
关键词：
Tetrac; SN38; integrin; targeted delivery; PLGA; chitosan; IN-VITRO; DRUG-DELIVERY; THYROID-HORMONE; TUMOR; CAMPTOTHECIN; POLYMERSOMES; DOXORUBICIN; PACLITAXEL; RESISTANCE; GROWTH;
D O I：
10.1080/21691401.2018.1477789
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
New integrin-targeted nanoparticles made of chitosan-stabilized PLGA matrix was developed to specifically target colon adenocarcinoma. To this aim, SN38-encapsulated chitosan-coated PLGA NPs were conjugated with tetrac for integrin receptor-guided delivery. To provide a sustained release pattern for SN38, it was loaded into nanoparticles using single emulsion method. The size of NPs were 174.23 +/- 6.12 nm with drug encapsulation efficiency and loading content of 73.16 +/- 11.15 and 4.45 +/- 0.31, respectively. The in vitro results confirmed that the designed nanoplatform showed specific cellular uptake and cytotoxicity in integrin overexpressing cancer cells and provided a sustained release profile for SN38. Additionally, an increased therapeutic potency of targeted formulation over both non-targeted and free drug was shown in vivo.
引用
收藏
页码：1003 / 1014
页数：12
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