Drug treatment of pruritus in liver diseases

被引：29
作者：
Hegade, Vinod S. [1 ,2 ]
Kendrick, Stuart F. W. [1 ,2 ]
Jones, David E. J. [1 ,2 ]
机构：
[1] Newcastle Upon Tyne Hosp NHS Fdn Trust, Freeman Hosp, Newcastle Upon Tyne, Tyne & Wear, England
[2] Newcastle Univ, Inst Cellular Med, Fac Med Sci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
来源：
CLINICAL MEDICINE | 2015年 / 15卷 / 04期
基金：
英国医学研究理事会;
关键词：
Pruritus; cholestasis; primary billary cirrhosis; liver disease; treatment; CHOLESTATIC PRURITUS; RAT MODEL; PATHOGENESIS; ACID; ANTAGONISTS; SERTRALINE; CIRRHOSIS; EFFICACY; RIFAMPIN; OPIOIDS;
D O I：
10.7861/clinmedicine.15-4-351
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pruritus (itch) is a common complication of cholestatic liver diseases (CLD). It can be a distressing and debilitating symptom, causing significant impairment in quality of life. Treatment of pruritus in liver diseases can be challenging and requires specific management with early initiation and a step-wise approach using specific drugs. Clinical trials are ongoing with novel agents that demonstrate potential efficacy. Patients with cholestatic pruritus are likely to present to a variety of clinicians who would benefit from medical awareness of available treatment options. In this review, we outline the pharmaceutical agents currently used to treat cholestatic pruritus and provide the evidence base for targeted symptom control of itch in liver diseases. We also highlight recent developments in the pathophysiology of cholestatic pruritus and the emerging novel therapies.
引用
收藏
页码：351 / 357
页数：7
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