Xenotropic murine leukaemia virus-related virus is not found in peripheral blood cells from treatment-naive human immunodeficiency virus-positive patients

被引：8
作者：
Maggi, F. [1 ]
Focosi, D. [2 ]
Lanini, L.
Sbranti, S.
Mazzetti, P.
Macera, L.
Davini, S. [2 ]
De Donno, M. [2 ]
Mariotti, M. L. [2 ]
Antonelli, G. [3 ]
Scatena, F. [2 ]
Pistello, M. [4 ,5 ]
机构：
[1] Azienda Osped Univ Pisana, Virol Unit, Pisa Univ Hosp, I-56127 Pisa, Italy
[2] Azienda Osped Univ Pisana, UO Immunoematol SSN, I-56127 Pisa, Italy
[3] Univ Roma La Sapienza, Dept Mol Med, Virol Lab, Rome, Italy
[4] Univ Pisa, Retrovirus Ctr, Pisa, Italy
[5] Univ Pisa, Virol Sect, Dept Expt Pathol, Pisa, Italy
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2012年 / 18卷 / 02期
关键词：
HIV; peripheral blood cells; real-time PCR; treatment-naive; xenotropic murine leukaemia virus-related virus; CHRONIC-FATIGUE-SYNDROME; PROSTATE-CANCER; INFECTIOUS RETROVIRUS; XMRV; PREVALENCE; FAILURE; ABSENCE; DETECT; CONTAMINATION; INDIVIDUALS;
D O I：
10.1111/j.1469-0691.2011.03580.x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The human pathogen xenotropic murine leukaemia virus-related virus (XMRV) has been tentatively associated with prostate cancer and chronic fatigue syndrome. Unfortunately, subsequent studies failed to identify the virus in various clinical settings. To determine whether XMRV circulates in humans and the relationship with its host, we searched for the virus in 124 human immunodeficiency virus-infected patients who might have been exposed to XMRV, might be prone to infection as a result of progressive immunodeficiency, and had not yet been treated with antiretroviral drugs. Using nested PCR and single-step TaqMan real-time PCR, both designed on the XMRV gag gene, we could not find any positive samples. These findings add to the growing amount of scepticism regarding XMRV.
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页码：184 / 188
页数：5
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