Zoledronic acid inhibits proliferation and impairs migration and invasion through downregulating VEGF and MMPs expression in human nasopharyngeal carcinoma cells

被引：42

作者：

Li, Xu-yuan ^{[1
]}

Lin, Ying-cheng ^{[1
]}

Huang, Wan-lan ^{[1
]}

Hong, Chao-qun ^{[2
]}

Chen, Jiong-yu ^{[2
]}

You, Yan-jie ^{[2
]}

Li, Wei-bing ^{[1
]}

机构：

[1] Shantou Univ, Coll Med, Dept Internal Med, Canc Hosp, Shantou 515031, Peoples R China

[2] Shantou Univ, Coll Med, Dept Lab, Canc Hosp, Shantou 515031, Peoples R China

来源：

MEDICAL ONCOLOGY | 2012年 / 29卷 / 02期

关键词：

Human nasopharyngeal carcinoma cell line; Invasion; Matrix metalloproteinases; Migration; Vascular endothelial growth factor; Zoledronic acid; EARLY BREAST-CANCER; TUMOR-GROWTH; BISPHOSPHONATES; METALLOPROTEINASES; SURVIVAL; THERAPY; DISEASE;

D O I：

10.1007/s12032-011-9904-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To demonstrate the effect of zoledronic acid in proliferation, invasion, and migration of human nasopharyngeal carcinoma cell HNE-1 and explore the potential role of VEGF, MMP-2, and MMP-9 proteins in vitro. Human nasopharyngeal carcinoma cell HNE-1 was exposed to various concentrations (0-40 mu mol/l) of zoledronic acid. Zoledronic acid inhibited proliferation of HNE-1 cells though not in a dose-dependent manner. Zoledronic acid had exerted a dose-dependent effect on the migration and invasion of HNE-1 cells. Both expressions of mRNA and protein of MMP2, MMP9, and VEGF were reduced, respectively, detected by RT-PCR and Western blot assays. These data suggested that zoledronic acid not only inhibited growth but also invasion and migration of HNE-1 cells in vitro. The anti-cancer action of zoledronic acid was partially associated with the suppression of VEGF expression and secretion and downregulating the expression of MMP2 and MMP9.

引用

页码：714 / 720

页数：7

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