Factors Influencing the Delivery Efficiency of Cancer Nanomedicines

被引：5
作者：
Ullah, Rahat [1 ]
Wazir, Junaid [1 ]
Khan, Farhan Ullah [1 ]
Diallo, Maladho Tanta [1 ]
Ihsan, Awais Ullah [1 ]
Mikrani, Reyaj [1 ]
Aquib, Md [2 ]
Zhou, Xiaohui [1 ,3 ,4 ]
机构：
[1] China Pharmaceut Univ, Dept Clin Pharm, Sch Basic Med & Clin Pharm, Nanjing 211198, Jiangsu, Peoples R China
[2] China Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, Nanjing 211198, Jiangsu, Peoples R China
[3] Nanjing Shuiximen Hosp, Dept Surg, Nanjing 211198, Jiangsu, Peoples R China
[4] Southeast Univ, Zhongda Hosp, Nanjing 210017, Jiangsu, Peoples R China
来源：
AAPS PHARMSCITECH | 2020年 / 21卷 / 04期
基金：
中国国家自然科学基金;
关键词：
cancer; nano medicine; nanomaterials; tumor microenvironment; controlled release; SYSTEMICALLY ADMINISTERED SIRNA; TUMOR-ASSOCIATED MACROPHAGES; CELL LUNG-CANCER; PROTEIN CORONA; DRUG-DELIVERY; LIPOSOMAL DOXORUBICIN; IN-VIVO; POLYMERIC NANOPARTICLES; RNA INTERFERENCE; PHASE-I;
D O I：
10.1208/s12249-020-01691-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The superiority of nanomedicine over conventional medicines in the treatment of cancer has gained immediate recognition worldwide. As traditional cancer therapies are nonspecific and detrimental to healthy cells, the ability of nanomedicine to release drugs to target tumor cells specifically instead of healthy cells has brought new hope to cancer patients. This review focuses on the effects of various factors of nanoparticles such as transport, concentration in cells, tumor microenvironment, interaction with protein, penetration, uptake by tumor cells, cancer cell mutations, and intracellular trafficking of the nanoparticle. Besides the history of nanomedicine, future perspectives of nanomedicines are also explored in this text.
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页数：16
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共 178 条
  • [1] A phase II trial of Cremorphor EL-free paclitaxel (Genexol-PM) and gemcitabine in patients with advanced non-small cell lung cancer
    Ahn, Hee Kyung
    Jung, Minkyu
    Sym, Sun Jin
    Shin, Dong Bok
    Kang, Shin Myung
    Kyung, Sun Young
    Park, Jeong-Woong
    Jeong, Sung Hwan
    Cho, Eun Kyung
    [J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2014, 74 (02) : 277 - 282
  • [2] Tumor-associated macrophages are predominant carriers of cyclodextrin-based nanoparticles into gliomas
    Alizadeh, Darya
    Zhang, Leying
    Hwang, Jungyeon
    Schluep, Thomas
    Badie, Behnam
    [J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2010, 6 (02) : 382 - 390
  • [3] [Anonymous], 2016, Prnewswire.com21 Apr
  • [4] High liposomal doxorubicin tumour tissue distribution, as determined by radiopharmaceutical labelling with 99mTc-LD, is associated with the response and survival of patients with unresectable pleural mesothelioma treated with a combination of liposomal doxorubicin and cisplatin
    Arrieta, Oscar
    Medina, Luis-Alberto
    Estrada-Lobato, Enrique
    Ramirez-Tirado, Laura-Alejandra
    Mendoza-Garcia, Victor-Osvaldo
    de la Garza-Salazar, Jaime
    [J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2014, 74 (01) : 211 - 215
  • [5] Histamine Induces Vascular Hyperpermeability by Increasing Blood Flow and Endothelial Barrier Disruption In Vivo
    Ashina, Kohei
    Tsubosaka, Yoshiki
    Nakamura, Tatsuro
    Omori, Keisuke
    Kobayashi, Koji
    Hori, Masatoshi
    Ozaki, Hiroshi
    Murata, Takahisa
    [J]. PLOS ONE, 2015, 10 (07):
  • [6] INTERCAPILLARY DISTANCE MEASUREMENT AS AN INDICATOR OF HYPOXIA IN CARCINOMA OF THE CERVIX UTERI
    AWWAD, HK
    ELNAGGAR, M
    MOCKTAR, N
    BARSOUM, M
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1986, 12 (08): : 1329 - 1333
  • [7] NEGATIVE STAINING OF PHOSPHOLIPIDS + THEIR STRUCTURAL MODIFICATION BY-SURFACE ACTIVE AGENTS AS OBSERVED IN ELECTRON MICROSCOPE
    BANGHAM, AD
    HORNE, RW
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1964, 8 (05) : 660 - &
  • [8] Doxil® - The first FDA-approved nano-drug: Lessons learned
    Barenholz, Yechezkel
    [J]. JOURNAL OF CONTROLLED RELEASE, 2012, 160 (02) : 117 - 134
  • [9] Emerging Applications for Ferumoxytol as a Contrast Agent in MRI
    Bashir, Mustafa R.
    Bhatti, Lubna
    Marin, Daniele
    Nelson, Rendon C.
    [J]. JOURNAL OF MAGNETIC RESONANCE IMAGING, 2015, 41 (04) : 884 - 898
  • [10] Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology
    Bertrand, Nicolas
    Wu, Jun
    Xu, Xiaoyang
    Kamaly, Nazila
    Farokhzad, Omid C.
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2014, 66 : 2 - 25
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