The spindle checkpoint

被引：312
作者：
Amon, A [1 ]
机构：
[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1999年 / 9卷 / 01期
关键词：
D O I：
10.1016/S0959-437X(99)80010-0
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Prior to sister-chromatid separation, the spindle checkpoint inhibits cell-cycle progression in response to a signal generated by mitotic spindle damage or by chromosomes that have not attached to microtubules. Recent work has shown that the spindle checkpoint inhibits cell-cycle progression by direct binding of components of the spindle checkpoint pathway to components of a specialized ubiquitin-conjugating system that is responsible for triggering sister-chromatid separation.
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收藏
页码：69 / 75
页数：7
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