Can what have we learnt about BCG vaccination in the last 20 years help us to design a better tuberculosis vaccine?

被引：24

作者：

Dockrell, Hazel M. ^{[1
]}

Butkeviciute, Egle ^{[1
]}

机构：

[1] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Dept Infect Biol, Keppel St, London WC1E 7HT, England

来源：

VACCINE | 2022年 / 40卷 / 11期

基金：

欧盟地平线“2020”; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

BCG; BCG vaccination; Tuberculosis; TB vaccines; Trained immunity; CALMETTE-GUERIN VACCINATION; SCHOOL-AGED CHILDREN; IMMUNE-RESPONSES; MYCOBACTERIUM-TUBERCULOSIS; NONSPECIFIC PROTECTION; RESPIRATORY-INFECTION; TRAINED IMMUNITY; INNATE IMMUNITY; CELLS; BIRTH;

D O I：

10.1016/j.vaccine.2021.01.068

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The BCG vaccine will, in 2021, have been in use for 100 years. Much remains to be understood, including the reasons for its variable efficacy against pulmonary tuberculosis in adults. This review will discuss what has been learnt about the BCG vaccine in the last two decades, and whether this new information can be exploited to improve its efficacy, by enhancing its ability to induce either antigen-specific and/or non-specific effects. Many factors affect both the immunogenicity of BCG and its protective efficacy, highlighting the challenges of working with a live vaccine in man, but new insights may enable us to exploit better what BCG can do.

引用

页码：1525 / 1533

页数：9

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