Emerging Technologies for Local Cancer Treatment

被引：57
作者：
Chua, Corrine Ying Xuan [1 ]
Ho, Jeremy [1 ,2 ]
Demaria, Sandra [3 ]
Ferrari, Mauro [4 ]
Grattoni, Alessandro [1 ,5 ,6 ]
机构：
[1] Houston Methodist Res Inst HMRI, Dept Nanomed, Houston, TX 77030 USA
[2] Weill Cornell Med, Weill Cornell Med Coll, Sch Med, New York, NY 10065 USA
[3] Weill Cornell Med, Dept Radiat Oncol, New York, NY 10065 USA
[4] Univ Washington, Sch Pharm, Box 357630,H375 Hlth Sci Bldg, Seattle, WA 98195 USA
[5] Houston Methodist Hosp, Dept Radiat Oncol, Houston, TX 77030 USA
[6] Houston Methodist Hosp, Dept Surg, Houston, TX 77030 USA
来源：
ADVANCED THERAPEUTICS | 2020年 / 3卷 / 09期
关键词：
cancer treatment; in situ delivery; intratumoral drug delivery technologies; intratumoral implants; local controlled release; RECOMBINANT HUMAN INTERLEUKIN-12; IMMUNE CHECKPOINT BLOCKADE; SQUAMOUS-CELL CARCINOMA; HIGH-RISK PATIENTS; DRUG-DELIVERY; PHOTOTHERMAL THERAPY; RADIATION-THERAPY; INTRATUMORAL IMMUNOTHERAPY; TUMOR MICROENVIRONMENT; 1ST-LINE TREATMENT;
D O I：
10.1002/adtp.202000027
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The fundamental limitations of systemic therapeutic administration have prompted the development of local drug delivery platforms as a solution to increase effectiveness and reduce side effects. By confining therapeutics to the site of disease, local delivery technologies can enhance therapeutic index. This review highlights recent advances and opportunities in local drug delivery strategies for cancer treatment in addition to challenges that need to be addressed to facilitate clinical translation. The benefits of local cancer treatment combined with technological advancements and increased understanding of the tumor microenvironment, present a prime breakthrough opportunity for safer and more effective therapies.
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页数：18
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