Glycolipid stimulators for NKT cells bearing invariant Vα19-Jα33 TCR α chains

被引：3
作者：
Shimamura, M. [1 ]
机构：
[1] Mitsubishi Kagaku Inst Life Sci, Tokyo 1948511, Japan
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 03期
关键词：
glycolipid; FTY720; NKT cell; invariant TCR; immunomodulator; non-classical MHC class I;
D O I：
10.2174/138955708783744119
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Attempts have been made to find specific antigens for a novel NKT cell subset bearing invariant V alpha 19-J alpha 33 TCR alpha chains (V alpha 19 NKT cell). Comprehensive examinations revealed substantial antigenic activity in synthetic mannosylceramide (ManCer) that was presented by MR1. Structural modification of the sphingosine moiety of ManCer improved antigenic activity to enhance either Th1 or Th2-promoting cytokine production by V 19 NKT cells. Such ManCer analogues will be useful for developing new therapies as immunomodulators.
引用
收藏
页码：285 / 289
页数：5
相关论文
共 33 条
  • [1] Mouse CD1-specific NK1 T cells: Development, specificity, and function
    Bendelac, A
    Rivera, MN
    Park, SH
    Roark, JH
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 : 535 - 562
  • [2] A SUBSET OF CD4(+) THYMOCYTES SELECTED BY MHC CLASS-I MOLECULES
    BENDELAC, A
    KILLEEN, N
    LITTMAN, DR
    SCHWARTZ, RH
    [J]. SCIENCE, 1994, 263 (5154) : 1774 - 1778
  • [3] CD1 RECOGNITION BY MOUSE NK1(+) T-LYMPHOCYTES
    BENDELAC, A
    LANTZ, O
    QUIMBY, ME
    YEWDELL, JW
    BENNINK, JR
    BRUTKIEWICZ, RR
    [J]. SCIENCE, 1995, 268 (5212) : 863 - 865
  • [4] GLYCOLIPIDS
    CARTER, HE
    JOHNSON, P
    WEBER, EJ
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1965, 34 : 109 - +
  • [5] Invariant Vα19i T cells regulate autoimmune inflammation
    Croxford, J. Ludovic
    Miyake, Sachiko
    Huang, Yi-Ying
    Shimamura, Michio
    Yamamura, Takashi
    [J]. NATURE IMMUNOLOGY, 2006, 7 (09) : 987 - 994
  • [6] Yeast sphingolipids
    Dickson, RC
    Lester, RL
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1999, 1426 (02): : 347 - 357
  • [7] 2-SUBSTITUTED 2-AMINOETHANOL - MINIMUM ESSENTIAL STRUCTURE FOR IMMUNOSUPPRESSIVE ACTIVITY OF ISP-I (MYRIOCIN)
    FUJITA, T
    HIROSE, R
    HAMAMICHI, N
    KITAO, Y
    SASAKI, S
    YONETA, M
    CHIBA, K
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (16) : 1857 - 1860
  • [8] Patterns of nonclassical MHC antigen presentation
    Hansen, Ted H.
    Huang, Shouxiong
    Arnold, Phoebe L.
    Fremont, Daved H.
    [J]. NATURE IMMUNOLOGY, 2007, 8 (06) : 563 - 568
  • [9] Evidence for MR1 antigen presentation to mucosal-associated invariant T cells
    Huang, SX
    Gilfillan, S
    Cella, M
    Miley, MJ
    Lantz, O
    Lybarger, L
    Fremont, DH
    Hansen, TH
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (22) : 21183 - 21193
  • [10] MR1-restricted Vα19i mucosal-associated invariant T cells are innate T cells in the gut lamina propria that provide a rapid and diverse cytokine response
    Kawachi, I
    Maldonado, J
    Strader, C
    Gilfillan, S
    [J]. JOURNAL OF IMMUNOLOGY, 2006, 176 (03) : 1618 - 1627
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