Current practice and evolving concepts in septic shock resuscitation

被引：68

作者：

Bakker, Jan ^{[1
,2
,3
,4
]}

Kattan, Eduardo ^{[4
]}

Annane, Djillali ^{[5
,6
]}

Castro, Ricardo ^{[4
]}

Cecconi, Maurizio ^{[7
,8
]}

de Backer, Daniel ^{[9
]}

Dubin, Arnaldo ^{[10
,11
]}

Evans, Laura ^{[12
]}

Gong, Michelle Ng ^{[13
]}

Hamzaoui, Olfa ^{[14
]}

Ince, Can ^{[1
]}

Levy, Bruno ^{[15
,16
,17
]}

Monnet, Xavier ^{[18
]}

Ospina Tascon, Gustavo A. ^{[19
]}

Ostermann, Marlies ^{[20
]}

Pinsky, Michal R. ^{[21
]}

Russell, James A. ^{[22
]}

Saugel, Bernd ^{[23
]}

Scheeren, Thomas W. L. ^{[24
]}

Teboul, Jean-Louis ^{[25
]}

Baron, Antoine Vieillard ^{[26
,27
]}

Vincent, Jean-Louis ^{[28
]}

Zampieri, Fernando G. ^{[29
,30
]}

Hernandez, Glenn ^{[4
]}

机构：

[1] Erasmus MC Univ, Dept Intens Care, Med Ctr, Rotterdam, Netherlands

[2] Columbia Univ, Dept Pulmonol & Crit Care, Med Ctr, New York, NY USA

[3] NYU, Sch Medicinel Langone, New York, NY USA

[4] Pontificia Univ Catolica Chile, Fac Med, Dept Med Intens, Santiago, Chile

[5] Hop Raymond Poincare, AP HP, Intens Care Unit, Garches, France

[6] Univ Versailles St Quentin en Yvelines, UFR Sci Sante Simone Veil, Montigny Le Bretonneux, France

[7] Humanitas Univ Pieve Emanuele, Dept Biomed Sci, Milan, Italy

[8] IRCCS Humanitas Res Hosp, Dept Anesthesia & Intens Care, Milan, Italy

[9] Univ Libre Bruxelles, CHIREC Hosp, Dept Intens Care, Brussels, Belgium

[10] Univ Nacl La Plata, Catedra Farmacol Aplicada, Fac Ciencias Med, La Plata, Argentina

[11] Sanatorio Otamendi, Buenos Aires, DF, Argentina

[12] Univ Washington, Dept Pulm & Crit Care Med, Seattle, WA USA

[13] Albert Einstein Coll Med, Dept Med, Div Crit Care Med, Div Pulm Med,Montefiore Healthcare Syst, Bronx, NY USA

[14] Univ Paris Saclay, Hop Antoine Beclere, AP HP, Serv Reanimat Polyvalente, F-92141 Clamart, France

[15] CHRU Nancy, Pole Cardio Med Chirurg, Serv Reanimat Med Brabois, Vandoeuvre Les Nancy, France

[16] INSERM, U1116, Fac Med, Vandoeuvre Les Nancy, France

[17] Univ Lorraine, Nancy, France

[18] Univ Ris Saclay, Hop Bicetre, AP HP,Grp Rech Clin CARMAS, Serv Med Intens Reanimat,DMU CORREVE,FHU SEPSIS,I, Le Kremlin Bicetre, France

[19] Univ ICESI, Dept Intens Care Med, Fdn Valle del Lili, Cali, Colombia

[20] Guys & St Thomas NHS Fdn Trust, Dept Crit Care, Kings Coll London, London, England

[21] Univ Pittsburgh, Dept Bioengn Anesthesiol & Cardiovasc Dis, Dept Crit Care Med, Pittsburgh, PA USA

[22] Univ British Columbia, Ctr Heart Lung Innovat, St Pauls Hosp, 1081 Burrard St, Vancouver, BC, Canada

[23] Univ Med Ctr Hamburg Eppendorf, Ctr Anesthesiol & Intens Care Med, Dept Anesthesiol, Hamburg, Germany

[24] Univ Groningen, Univ Med Ctr Groningen, Dept Anesthesiol, Groningen, Netherlands

[25] Univ Paris Saclay, Hop Bicetre, AP HP, Serv Med Intens Reanimat,Inserm UMR S 999, Le Kremlin Bicetre, France

[26] Ambroise Pare Hosp, AP HP, Med Intens Care Unit, Boulogne, France

[27] Paris Saclay Univ, CESP, Clin Epidemiol Team, INSERM UMR 1018, Villejuif, France

[28] Univ Libre Bruxelles, Erasme Univ Hosp, Dept Intens Care, Brussels, Belgium

[29] HCor Res Inst, Sao Paulo, Brazil

[30] DOr Res & Educ Inst, Sao Paulo, Brazil

来源：

INTENSIVE CARE MEDICINE | 2022年 / 48卷 / 02期

关键词：

Sepsis; Intensive care; Vasoactive drugs; Fluids; Fluid resuscitation; Treatment; ARTERIAL CARBON-DIOXIDE; ACUTE KIDNEY INJURY; CRITICALLY-ILL; SEVERE SEPSIS; MICROCIRCULATORY ALTERATIONS; SUBLINGUAL MICROCIRCULATION; NOREPINEPHRINE INFUSION; BALANCED CRYSTALLOIDS; EUROPEAN-SOCIETY; VENOUS RETURN;

D O I：

10.1007/s00134-021-06595-9

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Clinical and pathophysiological understanding of septic shock has progressed exponentially in the previous decades, translating into a steady decrease in septic shock-related morbidity and mortality. Even though large randomized, controlled trials have addressed fundamental aspects of septic shock resuscitation, many questions still exist. In this review, we will describe the current standards of septic shock resuscitation, but the emphasis will be placed on evolving concepts in different domains such as clinical resuscitation targets, adequate use of fluids and vasoactive drugs, refractory shock, and the use of extracorporeal therapies. Multiple research opportunities remain open, and collaborative endeavors should be performed to fill in these gaps.

引用

页码：148 / 163

页数：16

共 114 条

[1] Serious Adverse Events Associated With Vasopressin and Norepinephrine Infusion in Septic Shock [J].