Conestat alfa for the treatment of angioedema attacks

被引：22

作者：

Davis, Benjamin ^{[1
]}

Bernstein, Jonathan A. ^{[1
]}

机构：

[1] Univ Cincinnati, Coll Med, Dept Internal Med, Div Immunol,Allergy Sect, Cincinnati, OH USA

来源：

THERAPEUTICS AND CLINICAL RISK MANAGEMENT | 2011年 / 7卷

关键词：

androgens; adverse events; patients; HAE attacks; HUMAN C1 INHIBITOR; HEREDITARY ANGIONEUROTIC EDEMA; EPSILON-AMINOCAPROIC ACID; SERINE-PROTEASE INHIBITOR; FRESH-FROZEN PLASMA; LONG-TERM TREATMENT; ESTERASE INHIBITOR; ATTENUATED ANDROGENS; TRANSGENIC RABBITS; CLINICAL SYNDROME;

D O I：

10.2147/TCRM.S15544

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Recently, multiple C1 inhibitor (C1-INH) replacement products have been approved for the treatment of hereditary angioedema (HAE). This review summarizes HAE and its current treatment modalities and focuses on findings from bench to bedside trials of a new C1-INH replacement, conestat alfa. Conestat alfa is unique among the other C1-INH replacement products because it is produced from transgenic rabbits rather than derived from human plasma donors, which can potentially allow an unlimited source of drug without any concern of infectious transmission. The clinical trial data generated to date indicate that conestat alfa is safe and effective for the treatment of acute HAE attacks.

引用

页码：265 / 273

页数：9

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