Behavioral and neuroendocrine actions of endomorphin-2

被引：28
作者：
Bujdosó, E
Jászberényi, M
Tömböly, C
Tóth, G
Telegdy, G [1 ]
机构：
[1] Univ Szeged, Dept Pathophysiol, Neurohumoral Res Grp, Hungarian Acad Sci, Szeged, Hungary
[2] Hungarian Acad Sci, Biol Res Ctr, Inst Biochem, H-6701 Szeged, Hungary
来源：
PEPTIDES | 2001年 / 22卷 / 09期
基金：
新加坡国家研究基金会;
关键词：
endomorphin-2; open-field behavior; HPA axis;
D O I：
10.1016/S0196-9781(01)00466-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effects of intracerebroventricularly administered endomorphin-2 (EM2) on open-field activity and the hypothalamo-pituitary-adrenal (HPA) system were investigated. EM2 (0.25-1 mug) significantly increased both the locomotor and the rearing activity, resulting in a bell-shaped dose-response curve. EM2 also enhanced corticosterone release, with an even more profound downturn phase at higher concentrations. The corticotropin-releasing hormone (CRH) antagonist a-helical CRH9-41 completely abolished the EM2-evoked endocrine and behavioral responses. These findings reinforce the hypothesis that the endomorphins may play a significant role in the regulation of locomotion, rearing activity and the HPA system through the release of CRH. (C) 2001 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：1459 / 1463
页数：5
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