Y-box-binding protein 1 stimulates abasic site cleavage

被引：7

作者：

Alemasova, E. E. ^{[1
]}

Naumenko, K. N. ^{[1
,2
]}

Moor, N. A. ^{[1
]}

Lavrik, O. I. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Inst Chem Biol & Fundamental Med, Siberian Branch, Novosibirsk 630090, Russia

[2] Novosibirsk State Univ, Novosibirsk 630090, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2017年 / 82卷 / 12期

基金：

俄罗斯科学基金会;

关键词：

Y-box-binding protein 1; AP endonuclease 1; base excision repair; apurinic/apyrimidinic site; HUMAN APURINIC/APYRIMIDINIC ENDONUCLEASE; CATION-PI INTERACTIONS; BASE EXCISION-REPAIR; DIVALENT METAL-IONS; DNA-REPAIR; LYSINE RESIDUES; ACTIVE-SITE; APE1; APE1/REF-1; CELLS;

D O I：

10.1134/S0006297917120112

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apurinic/apyrimidinic (AP) sites are among the most frequent DNA lesions. The first step in the AP site repair involves the magnesium-dependent enzyme AP endonuclease 1 (APE1) that catalyzes hydrolytic cleavage of the DNA phosphodiester bond at the 5' side of the AP site, thereby generating a single-strand DNA break flanked by the 3'-OH and 5'-deoxyribose phosphate (dRP) groups. Increased APE1 activity in cancer cells might correlate with tumor chemoresistance to DNA-damaging treatment. It has been previously shown that the multifunctional oncoprotein Y-box-binding protein 1 (YB-1) interacts with APE1 and inhibits APE1-catalyzed hydrolysis of AP sites in single-stranded DNAs. In this work, we demonstrated that YB-1 stabilizes the APE1 complex with double-stranded DNAs containing the AP sites and stimulates cleavage of these AP sites at low magnesium concentrations.

引用

页码：1521 / 1528

页数：8

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