Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition

被引：77

作者：

Clark, CJ

Mackay, GM

Smythe, GA

Bustamante, S

Stone, TW

Phillips, RS

机构：

[1] Univ Glasgow, Div Infect & Immun, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland

[2] Univ New S Wales, Biomed Mass Spectrometry Facil, Sydney, NSW 2052, Australia

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 08期

关键词：

D O I：

10.1128/IAI.73.8.5249-5251.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

C57BL/6J mice infected with Plasmodium berghei ANKA develop neurological dysfunction and die within 7 days of infection. We show that treatment of infected mice with a kynurenine-3-hvdroxylase inhibitor prevents them from developing neurological symptoms and extends their life span threefold until severe anemia develops.

引用

页码：5249 / 5251

页数：3

共 21 条

[1] AlberatiGiani D, 1996, J NEUROCHEM, V66, P996
[2] The tryptophan catabolite picolinic acid selectively induces the chemokines macrophage inflammatory protein-1α and-1β in macrophages
Bosco, MC
Rapisarda, A
Massazza, S
Melillo, G
Young, H
Varesio, L
[J]. JOURNAL OF IMMUNOLOGY, 2000, 164 (06) : 3283 - 3291
[3] BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[4] Cytokine and chemokine mRNA expression in neutrophils from CBA/NSlc mice infected with Plasmodium berghei ANKA that induces experimental cerebral malaria
Chen, L
Sendo, F
[J]. PARASITOLOGY INTERNATIONAL, 2001, 50 (02) : 139 - 143
[5] Quinolinic acid formation in immune-activated mice:: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(-3-nitrophenyl) thiazol-2yl]-benzenesulfonamide (Ro 61-8048), two potent and selective inhibitors of kynurenine hydroxylase
Chiarugi, A
Moroni, F
[J]. NEUROPHARMACOLOGY, 1999, 38 (08) : 1225 - 1233
[6] Differences in the neurochemical characteristics of the cortex and striatum of mice with cerebral malaria
Clark, CJ
Phillips, RS
McMillan, RB
Montgomery, IO
Stone, TW
[J]. PARASITOLOGY, 2005, 130 : 23 - 29
[7] Cerebrospinal fluid studies in children with cerebral malaria: An excitotoxic mechanism?
Dobbie, M
Crawley, J
Waruiru, C
Marsh, K
Surtees, R
[J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2000, 62 (02) : 284 - 290
[8] Activated human microglia produce the excitotoxin quinolinic acid
Espey, MG
Chernyshev, ON
Reinhard, JF
Namboodiri, MAA
Colton, CA
[J]. NEUROREPORT, 1997, 8 (02) : 431 - 434
[9] MK-801 and 7-Ni attenuate the activation of brain NF-κB induced by LPS
Glezer, I
Munhoz, CD
Kawamoto, EM
Marcourakis, T
Avellar, MCW
Scavone, C
[J]. NEUROPHARMACOLOGY, 2003, 45 (08) : 1120 - 1129
[10] Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria
Hunt, NH
Grau, GE
[J]. TRENDS IN IMMUNOLOGY, 2003, 24 (09) : 491 - 499

← 1 2 3 →