Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition

被引:77
作者
Clark, CJ
Mackay, GM
Smythe, GA
Bustamante, S
Stone, TW
Phillips, RS
机构
[1] Univ Glasgow, Div Infect & Immun, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland
[2] Univ New S Wales, Biomed Mass Spectrometry Facil, Sydney, NSW 2052, Australia
关键词
D O I
10.1128/IAI.73.8.5249-5251.2005
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
C57BL/6J mice infected with Plasmodium berghei ANKA develop neurological dysfunction and die within 7 days of infection. We show that treatment of infected mice with a kynurenine-3-hvdroxylase inhibitor prevents them from developing neurological symptoms and extends their life span threefold until severe anemia develops.
引用
收藏
页码:5249 / 5251
页数:3
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