TGF-β1 and BRCA2 Expression are Associated with Clinical Factors in Breast Cancer

被引：7
作者：
Li, Junchuan [1 ,2 ]
Zhu, Hongyu [1 ,2 ]
Chen, Tingxuan [1 ,2 ]
Dai, Guihua [1 ,2 ]
Zou, Lanying [2 ]
机构：
[1] Yangtze Univ, Affiliated Hosp 1, Dept Pathol, Jinzhou 434000, Hubei, Peoples R China
[2] Jingzhou First People Hosp, Jinzhou 434000, Hubei, Peoples R China
来源：
CELL BIOCHEMISTRY AND BIOPHYSICS | 2011年 / 60卷 / 03期
关键词：
Breast cancer genetics; TGF-beta; BRCA2; HER2; CARRIERS; RISK;
D O I：
10.1007/s12013-010-9146-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The objective of this study was to investigate the possible association between the expression of transforming growth factor beta-1 (TGF-beta 1) and breast cancer type2 susceptibility protein (BRCA2) with clinical factors in breast cancer. TGF-beta 1, BRCA2, human epidermal growth factor receptor2 (HER2), estrogen receptor, and progesterone receptor protein levels were measured in 67 samples from breast cancer patients by immunohistochemistry. The expression of these proteins was correlated with various clinical factors including age, pathohistological grade and status of axillary lymph node implication. TGF-beta 1 and BRCA2 were expressed in breast cancer tissues and expression of HER2 and TGF-beta 1 was significantly correlated with BRCA2. The authors conclude that elevated expression of BRCA2 correlates with TGF-beta 1 and HER2 in breast cancer and these three factors act in synergy to promote cancer. Thus, detection of both TGF-beta 1 and BRCA2 may therefore assist in the prognosis and treatment of breast cancer.
引用
收藏
页码：245 / 248
页数：4
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