Carboplatin-induced renal salt-wasting syndrome in pediatric patients with intracranial germ cell tumors and concomitant diabetes insipidus

被引:2
作者
Wan, Tania [1 ]
Tung, Joanna Yuet-Ling [1 ]
Ma, Alison [1 ]
Lee, Samantha Lai-Ka [1 ]
Liu, Anthony Pak-Yin [1 ]
Ku, Dennis Tak-Loi [1 ]
Yau, Ping-Wa [1 ]
Shing, Matthew Ming-Kong [1 ]
机构
[1] Hong Kong Childrens Hosp, Dept Paediat & Adolescent Med, Kowloon, 1 Shing Cheong Rd, Hong Kong, Peoples R China
关键词
carboplatin; germ cell tumor; pediatrics; renal salt-wasting syndrome; CISPLATIN; CHEMOTHERAPY; MANIFESTATIONS; HYPONATREMIA; CHILDREN;
D O I
10.1002/pbc.29592
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We report a case series of 14 children with intracranial germ cell tumor and concomitant central diabetes insipidus, who developed hyponatremia secondary to renal salt-wasting syndrome (RSWS) following the administration of carboplatin. Clinicians prescribing platinum-based chemotherapy for this group of patients should be alert to the risk of RSWS. Regular monitoring should be performed as hyponatremia can be asymptomatic until it is severe.
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页数:4
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