5-Azacytidine as Salvage Treatment in Relapsed Myeloid Tumors after Allogeneic Bone Marrow Transplantation

被引：49

作者：

Bolanos-Meade, Javier ^{[1
]}

Smith, B. Douglas

Gore, Steven D.

McDevitt, Michael A.

Luznik, Leo

Fuchs, Ephraim J.

Jones, Richard J.

机构：

[1] Sidney Kimmel Comprehens Canc Ctr johns Hopkins, George W Santos Bone Marrow Transplant Serv, Dept Oncol, Baltimore, MD 21231 USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2011年 / 17卷 / 05期

关键词：

Acute myeloid leukemia; Donor lymphocyte infusion; 5-Azacytidine; Myelodysplastic syndrome; Graft-versus-host disease; STEM-CELL TRANSPLANTATION; DONOR LYMPHOCYTE INFUSIONS; CONVENTIONAL CARE REGIMENS; VERSUS-HOST-DISEASE; CLASS-I ANTIGENS; MYELODYSPLASTIC SYNDROME; ACUTE-LEUKEMIA; UP-REGULATION; AZACITIDINE; 5-AZA-2'-DEOXYCYTIDINE;

D O I：

10.1016/j.bbmt.2010.10.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Relapse after allogeneic blood or marrow transplantation carries a very poor prognosis. Current strategies for management that include donor lymphocyte infusions (DLIs) and salvage chemotherapies are usually toxic and ineffective. Here we report the outcome of 10 patients with myeloid malignancies that received 5-azacytidine after a failed allogeneic bone marrow transplant. Of the 10 patients, 6 achieved a complete remission, 1 had stable disease, and 3 progressed after a median of 6 cycles administered. Only 1 patient has died (of disease progression), and no flares of graft-versus-host disease (GVHD) were observed with 5-azacytidine. As of latest follow-up, the median overall survival (OS) for the group was 422.5 days (127-1411). These results further suggest that 5-azacytidine is an active agent after failing an allogeneic bone marrow transplant, and prospective studies are warranted. Biol Blood Marrow Transplant 17: 754-758 (2011) (C) 2011 American Society for Blood and Marrow Transplantation

引用

页码：754 / 758

页数：5

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