The hepatocyte in the innate immunity

被引：6

作者：

Zhang, Wen-Juan ^{[1
,2
,3
]}

Li, Ke-Yun ^{[1
]}

Huang, Bin-Hong ^{[1
]}

Wang, Hui ^{[3
]}

Wan, Shao-Gui ^{[4
]}

Zhou, Shun-Chang ^{[5
]}

机构：

[1] Gannan Med Univ, Sch Basic Med, Dept Immunol, Ganzhou 341000, Jiangxi, Peoples R China

[2] Gannan Med Univ, Key Lab Prevent & Treatment Cardiovasc & Cerebrova, Minist Educ, Ganzhou 341000, Jiangxi, Peoples R China

[3] Xinxiang Med Univ, Henan Key Lab Immunol & Targeted Drugs, Xinxiang 453003, Henan, Peoples R China

[4] Gannan Med Univ, Ctr Mol Pathol, Sch Basic Med, Ganzhou 341000, Jiangxi, Peoples R China

[5] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Expt Anim, Wuhan 430030, Hubei, Peoples R China

来源：

VIROLOGY | 2022年 / 576卷

关键词：

Hepatocytes; Innate immune receptors; RIG; NLRs; TLRs; NLRP3; INFLAMMASOME; LIPID-ACCUMULATION; VIRUS-REPLICATION; ACTIVATION; INFECTION; RECEPTOR; PLAYS; HEPG2;

D O I：

10.1016/j.virol.2022.09.011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The hepatocytes, as the main cells in the liver, exert liver functions by expressing innate immune receptors. The innate immune receptors include Toll-like receptors (TLRs), RIG-like receptors (retinoic acid inducible gene I-like receptors, RLRs) and NOD-like receptors (nucleotide binding oligomerization domain-like receptors, NLRs). The hepatocytes, recognize extracellular pathogen-associated molecular patterns (PAMPs) and intracellular damage -associated molecular patterns (DAMPs) through the above receptors. After the activation of the innate immune receptors, the hepatocytes produce cytokines, such as interferon (IFN), to protect the liver, through a series of signaling cascades.

引用

页码：111 / 116

页数：6

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