Liensinine Inhibits Cell Growth and Blocks Autophagic Flux in Nonsmall-Cell Lung Cancer

被引：10

作者：

Chang, Minghui ^{[1
]}

Ding, Shanshan ^{[1
]}

Dong, Xiaohan ^{[1
]}

Shang, Xiaoling ^{[1
]}

Li, Yang ^{[2
]}

Xie, Li ^{[1
]}

Song, Xingguo ^{[1
]}

Song, Xianrang ^{[1
,2
]}

机构：

[1] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Clin Lab, Jinan, Shandong, Peoples R China

[2] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Shandong Prov Key Lab Radiat Oncol, Jinan, Shandong, Peoples R China

来源：

JOURNAL OF ONCOLOGY | 2022年 / 2022卷

基金：

中国国家自然科学基金;

关键词：

MITOCHONDRIAL-DNA DAMAGE; ROS GENERATION; METABOLISM; REPAIR; HEALTH;

D O I：

10.1155/2022/1533779

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Liensinine is a bioactive component of Plumula Nelumbinis extracted from the green embryo of the mature seeds of Nelumbonaceae and exhibits therapeutic functions and noteworthy anti-tumor effects in recent studies. However, the potential anti-tumor property and the underlying mechanisms of liensinine in nonsmall-cell lung cancer (NSCLC) have not been illustrated. In this study, we demonstrated that liensinine has the potential anti-tumor property, and it could inhibit growth of NSCLC in vitro and in vivo. In addition, we found that although it induced significant accumulation of autophagosomes, liensinine could quench them for degradation and blocked autophagic flux. Importantly, we observed that liensinine inhibited the normal function of mitochondrial energy supply and impaired the lysosomal function. This research firstly provides a possibility insight that liensinine could be a novel therapeutic strategy for NSCLC.

引用

页数：17

共 37 条

[1] Small-molecule inhibitors of human mitochondrial DNA transcription [J].

Bonekamp, Nina A. ;

Peter, Bradley ;

Hillen, Hauke S. ;

Felser, Andrea ;

Bergbrede, Tim ;

Choidas, Axel ;

Horn, Moritz ;

Unger, Anke ;

Di Lucrezia, Raffaella ;

Atanassov, Ilian ;

Li, Xinping ;

Koch, Uwe ;

Menninger, Sascha ;

Boros, Joanna ;

Habenberger, Peter ;

Giavalisco, Patrick ;

Cramer, Patrick ;

Denzel, Martin S. ;

Nussbaumer, Peter ;

Klebl, Bert ;

Falkenberg, Maria ;

Gustafsson, Claes M. ;

Larsson, Nils-Goeran .

NATURE, 2020, 588 (7839) :712-+

[2]

Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21492, 10.3322/caac.21609]

[3] Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis [J].

Cai, Zhen ;

Li, Chien-Feng ;

Han, Fei ;

Liu, Chunfang ;

Zhang, Anmei ;

Hsu, Che-Chia ;

Peng, Danni ;

Zhang, Xian ;

Jin, Guoxiang ;

Rezaeian, Abdol-Hossein ;

Wang, Guihua ;

Zhang, Weina ;

Pan, Bo-Syong ;

Wang, Chi-Yun ;

Wang, Yu-Hui ;

Wu, Shih-Ying ;

Yang, Shun-Chin ;

Hsu, Fang-Chi ;

D'Agostino, Ralph B., Jr. ;

Furdui, Christina M. ;

Kucera, Gregory L. ;

Parks, John S. ;

Chilton, Floyd H. ;

Huang, Chih-Yang ;

Tsai, Fuu-Jen ;

Pasche, Boris ;

Watabe, Kounosuke ;

Lin, Hui-Kuan .

MOLECULAR CELL, 2020, 80 (02) :263-+

[4] AMPK signalling in health and disease [J].

Carling, David .

CURRENT OPINION IN CELL BIOLOGY, 2017, 45 :31-37

[5] Plumula Nelumbinis: A review of traditional uses, phytochemistry, pharmacology, pharmacokinetics and safety [J].

Chen, Sixuan ;

Li, Xuping ;

Wu, Junxuan ;

Li, Jingyan ;

Xiao, Mingzhu ;

Yang, Ying ;

Liu, Zhongqiu ;

Cheng, Yuanyuan .

JOURNAL OF ETHNOPHARMACOLOGY, 2021, 266

[6] Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis [J].

Cheng, Gang ;

Zhang, Qi ;

Pan, Jing ;

Lee, Yongik ;

Ouari, Olivier ;

Hardy, Micael ;

Zielonka, Monika ;

Myers, Charles R. ;

Zielonka, Jacek ;

Weh, Katherine ;

Chang, Andrew C. ;

Chen, Guoan ;

Kresty, Laura ;

Kalyanaraman, Balaraman ;

You, Ming .

NATURE COMMUNICATIONS, 2019, 10 (1)

[7] Non-Small Cell Lung Cancer, Version 5.2017 Clinical Practice Guidelines in Oncology [J].

Ettinger, David S. ;

Wood, Douglas E. ;

Aisner, Dara L. ;

Akerley, Wallace ;

Bauman, Jessica ;

Chirieac, Lucian R. ;

D'Amico, Thomas A. ;

DeCamp, Malcolm M. ;

Dilling, Thomas J. ;

Dobelbower, Michael ;

Doebele, Robert C. ;

Govindan, Ramaswamy ;

Gubens, Matthew A. ;

Hennon, Mark ;

Horn, Leora ;

Komaki, Ritsuko ;

Lackner, Rudy P. ;

Lanuti, Michael ;

Leal, Ticiana A. ;

Leisch, Leah J. ;

Lilenbaum, Rogerio ;

Lin, Jules ;

Loo, Billy W., Jr. ;

Martins, Renato ;

Otterson, Gregory A. ;

Reckamp, Karen ;

Riely, Gregory J. ;

Schild, Steven E. ;

Shapiro, Theresa A. ;

Stevenson, James ;

Swanson, Scott J. ;

Tauer, Kurt ;

Yang, Stephen C. ;

Gregory, Kristina ;

Hughes, Miranda .

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2017, 15 (04) :504-535

[8]

Furda A, 2014, METHODS MOL BIOL, V1105, P419, DOI 10.1007/978-1-62703-739-6_31

[9] Nimbolide, a Limonoid Triterpene, Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing the Proinflammatory Microenvironment [J].

Gupta, Subash C. ;

Prasad, Sahdeo ;

Sethumadhavan, Dhanya R. ;

Nair, Mangalam S. ;

Mo, Yin-Yuan ;

Aggarwal, Bharat B. .

CLINICAL CANCER RESEARCH, 2013, 19 (16) :4465-4476

[10] The biology and management of non-small cell lung cancer [J].

Herbst, Roy S. ;

Morgensztern, Daniel ;

Boshoff, Chris .

NATURE, 2018, 553 (7689) :446-454

← 1 2 3 4 →