Collagen Coated Nanoliposome as a Targeted and Controlled Drug Delivery System

被引：3

作者：

Krishnamoorthy, G. ^{[1
]}

Stephen, P. ^{[1
]}

Prabhu, M. ^{[1
]}

Sehgal, P. K. ^{[1
]}

Sadulla, S. ^{[1
]}

机构：

[1] CSIR, Cent Leather Res Inst, Bioprod Lab, Madras 20, Tamil Nadu, India

来源：

INTERNATIONAL CONFERENCE ON ADVANCED NANOMATERIALS AND NANOTECHNOLOGY (ICANN 2009) | 2010年 / 1276卷

关键词：

Collagen; Liposome; Nanoliposome; Collagen coated nanoliposome; Drug delivery system; I COLLAGEN; BIOMEDICAL APPLICATIONS; LIPOSOMES; BIOMATERIAL; PROTEIN;

D O I：

10.1063/1.3504292

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The collagen coated nanoliposome (CCNL) have been prepared and characterized in order to develop a targeted and controlled drug delivery system. The zeta potential (ZP) measurement, Fourier transform infrared (FT-IR) spectral and Scanning Electron Microscopy (SEM) and Cell viability assay data showed that the collagen coated nanoliposome particle size and charges, structural interaction and surface morphology and high bio-cyto-compatibility of collagen coated nanoliposome. The particle sizes of nanoliposome (NL) and collagen coated nanoliposome are 20-300 nm and 0.1-10 mu m respectively. The introduction of triple helical, coiled coil and fibrous protein of collagen into nanoliposome can improves the stability of nanoliposome, resistant to phospholipase activities and decreasing the phagocytosis of liposomes by reticuloendothelial system. The collagen coated nanoliposome is expected to be used as for targeted and controlled drug delivery system, and tissue engineering application.

引用

页码：163 / 168

页数：6

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