Importance of serological tests in diagnosis of autoimmune blistering diseases

被引：10

作者：

Ishii, Ken ^{[1
]}

机构：

[1] Toho Univ, Omori Med Ctr, Dept Dermatol, Tokyo 1438541, Japan

来源：

JOURNAL OF DERMATOLOGY | 2015年 / 42卷 / 01期

关键词：

autoantibodies; autoimmunity; bullous pemphigoid; immunoassays; pemphigus; LINKED-IMMUNOSORBENT-ASSAY; EPIDERMOLYSIS-BULLOSA-ACQUISITA; TERMINAL ADHESIVE REGION; PARANEOPLASTIC PEMPHIGUS; VII COLLAGEN; DESMOGLEIN; PHAGE DISPLAY; RECOMBINANT DESMOGLEINS; IGA PEMPHIGUS; NEONATAL MICE;

D O I：

10.1111/1346-8138.12703

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Autoimmune blistering diseases are organ-specific autoimmune diseases characterized by autoantibodies against structural proteins that maintain cell-cell (pemphigus diseases) and cell-matrix adhesions (pemphigoid diseases) in the skin and mucous membranes. Over the last few decades, identification of autoantigens and extensive characterization of autoantibodies have improved understanding of the pathogenesis of these diseases. In addition, the development of new sensitive and specific immunoassays enabled accurate diagnosis and proper evaluation of disease activity in autoimmune blistering diseases. In this review, we describe practical updates for molecular diagnostic tests for autoimmune blistering diseases and the basis for interpreting the results of the assays.

引用

页码：3 / 10

页数：8

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