Assessing Neuronal Metabolism In Vivo by Modeling Imaging Measures

被引：38

作者：

Ciccarelli, Olga ^{[1
]}

Toosy, Ahmed T. ^{[1
]}

De Stefano, Nicola ^{[2
]}

Wheeler-Kingshott, Claudia A. M. ^{[3
]}

Miller, David H. ^{[3
]}

Thompson, Alan J. ^{[1
]}

机构：

[1] UCL, Inst Neurol, Dept Brain Repair & Rehabil, NMR Unit, London WC1N 3BG, England

[2] Univ Siena, Dept Neurol & Behav Sci, I-53100 Siena, Italy

[3] UCL, Inst Neurol, Dept Neuroinflammat, NMR Unit, London WC1N 3BG, England

来源：

JOURNAL OF NEUROSCIENCE | 2010年 / 30卷 / 45期

基金：

英国惠康基金;

关键词：

MULTIPLE-SCLEROSIS PATIENTS; SPINAL-CORD; DISEASE PROGRESSION; DISABILITY; ATROPHY; MS;

D O I：

10.1523/JNEUROSCI.3330-10.2010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mitochondrial dysfunction contributes to the pathogenesis of many neurological diseases, including multiple sclerosis (MS), but is not directly measurable in vivo. We modeled N-acetyl-aspartate (NAA), which reflects axonal structural integrity and mitochondrial metabolism, with imaging measures of axonal structural integrity (axial diffusivity and cord cross-sectional area) to extract its mitochondrial metabolic contribution. Lower residual variance in NAA, reflecting reduced mitochondrial metabolism, was associated with greater clinical disability in MS, independent of structural damage.

引用

页码：15030 / 15033

页数：4

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