Detection of heavy metal ions using whispering gallery mode lasing in functionalized liquid crystal microdroplets

被引：47
作者：
Duan, Rui [1 ,2 ]
Li, Yanzeng [3 ]
Li, Hanyang [1 ,2 ,3 ]
Yang, Jun [2 ,4 ]
机构：
[1] Harbin Engn Univ, Coll Phys & Photoelect Engn, Harbin 150001, Heilongjiang, Peoples R China
[2] Harbin Engn Univ, Key Lab In Fiber Integrated Opt, Minist Educ China, Harbin 150080, Heilongjiang, Peoples R China
[3] Univ North Carolina Charlotte, Dept Phys & Opt Sci, Charlotte, NC 28223 USA
[4] Guangdong Univ Technol, Sch Informat Engn, Guangzhou 510008, Guangdong, Peoples R China
来源：
BIOMEDICAL OPTICS EXPRESS | 2019年 / 10卷 / 12期
基金：
中国国家自然科学基金;
关键词：
LABEL-FREE; BIOSENSOR; SENSORS; SURFACES;
D O I：
10.1364/BOE.10.006073
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We demonstrate a detection method for heavy metal (HM) ions based on whispering gallery mode (WGM) lasing in a liquid crystal (LC) microdroplet biosensor. By doping with stearic acid, nematic LC 4-cyano-4'-pentylbiphenyl (5CB) microdroplets are biochemically functionalized and used as both optical microresonators and sensing elements. Typical WGM lasing emission is observed in stearic acid-doped 5CB microdroplets under a pulse laser pump. Our results show that quantitative spectral shift of WGMs can serve as a real-time indicator of the adsorption of HM ions on the microdroplet surface. The detection limit of our sensor is as low as 40 pM for Cu(II) ions, six orders of magnitude better than the exposure threshold defined by the World Health Organization. Furthermore, this sensing system has an ability to discriminate between heavy and light metal ions. We believe that this novel biosensor has great application potential for environmental monitoring and drinking water quality testing. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
引用
收藏
页码：6073 / 6083
页数：11
相关论文
共 48 条
[1]   Label-free, single-molecule detection with optical microcavities [J].
Armani, Andrea M. ;
Kulkarni, Rajan P. ;
Fraser, Scott E. ;
Flagan, Richard C. ;
Vahala, Kerry J. .
SCIENCE, 2007, 317 (5839) :783-787
[2]  
Ashish B., 2013, Res. J. Recent Sci, V2, P58
[3]   Comparison of digestion methods for ICP-MS determination of trace elements in fish tissues [J].
Ashoka, Shailini ;
Peake, Barrie M. ;
Bremner, Graeme ;
Hageman, Kimberly J. ;
Reid, Malcolm R. .
ANALYTICA CHIMICA ACTA, 2009, 653 (02) :191-199
[4]   Atomic spectroscopy [J].
Bings, Nicolas H. ;
Bogaerts, Annemie ;
Broekaert, Jose A. C. .
ANALYTICAL CHEMISTRY, 2006, 78 (12) :3917-3945
[5]   Biomolecular interactions at phospholipid-decorated surfaces of liquid crystals [J].
Brake, JM ;
Daschner, MK ;
Luk, YY ;
Abbott, NL .
SCIENCE, 2003, 302 (5653) :2094-2097
[6]   Chemical and biological sensing using liquid crystals [J].
Carlton, Rebecca J. ;
Hunter, Jacob T. ;
Miller, Daniel S. ;
Abbasi, Reza ;
Mushenheim, Peter C. ;
Tan, Lie Na ;
Abbott, Nicholas L. .
LIQUID CRYSTALS REVIEWS, 2013, 1 (01) :29-51
[7]   A liquid crystal biosensor for detecting organophosphates through the localized pH changes induced by their hydrolytic products [J].
Chen, Chih-Hsin ;
Yang, Kun-Lin .
SENSORS AND ACTUATORS B-CHEMICAL, 2013, 181 :368-374
[8]   Label-free, color-indicating, and sensitive biosensors of cholesteric liquid crystals on a single vertically aligned substrate [J].
Chen, Fu-Lun ;
Fan, Yu-Jui ;
Lin, Jia-De ;
Hsiao, Yu-Cheng .
BIOMEDICAL OPTICS EXPRESS, 2019, 10 (09) :4636-4642
[9]   Bending-Induced Bidirectional Tuning of Whispering Gallery Mode Lasing from Flexible Polymer Fibers [J].
Chen, Rui ;
Ta, Van Duong ;
Sun, Handong .
ACS PHOTONICS, 2014, 1 (01) :11-16
[10]  
Duruibe JO, 2007, INT J PHYS SCI, V2, P112
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