We studied the reliability of Organic Light-Emitting Diodes (OLEDs) featuring a NPD hole transport layer and Alq(3) electron transport layer, subjected to thermal and electrical stress. The main results can be summarized as follows: temperature alone (without bias) cannot induce device degradation at least up to 60 degrees C; during constant current stress at 120 mA/cm(2), temperature can strongly enhance the degradation rate, even though the temperature increases only by 40 degrees C; the degradation is more severe in the central part of the device where the self-heating is larger. (C) 2010 Elsevier Ltd. All rights reserved.